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BMS-986242

Name: BMS-986242
Brand: TargetMol
SKU: T9164
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9164Cas No. 1923844-48-7

Alias BMS986242

BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.

BMS-986242

🥰Excellent

Purity: 98.9%

Catalog No. T9164Alias BMS986242Cas No. 1923844-48-7

BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$107	In Stock
10 mg	$167	In Stock
25 mg	$273	In Stock
50 mg	$385	In Stock
100 mg	$533	In Stock
1 mL x 10 mM (in DMSO)	$121	In Stock

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Purity:98.9%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.
In vitro	BMS-986242 demonstrates a higher propensity for oxidative metabolism and reduced susceptibility to glucuronidation. It exhibits an IC50 greater than 25 μM for all targets except for nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50 greater than 6 μM with approximately 20% maximum inhibition).
In vivo	BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) demonstrates dose-proportional exposure and significantly reduces tumor kynurenine concentration at all three doses.
Synonyms	BMS986242

Chemical Properties

Molecular Weight	410.91
Formula	C₂₄H₂₄ClFN₂O
Cas No.	1923844-48-7
Smiles	[H][C@]1(CC[C@@H](CC1)c1ccnc2ccc(F)cc12)[C@@H](C)NC(=O)c1ccc(Cl)cc1
Relative Density.	1.228 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (608.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4336 mL	12.1681 mL	24.3362 mL	121.6811 mL
5 mM	0.4867 mL	2.4336 mL	4.8672 mL	24.3362 mL
10 mM	0.2434 mL	1.2168 mL	2.4336 mL	12.1681 mL
20 mM	0.1217 mL	0.6084 mL	1.2168 mL	6.0841 mL
50 mM	0.0487 mL	0.2434 mL	0.4867 mL	2.4336 mL
100 mM	0.0243 mL	0.1217 mL	0.2434 mL	1.2168 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc