Shopping Cart

Remove All
Your shopping cart is currently empty

Glycyrrhizic acid

Name: Glycyrrhizic acid
Brand: TargetMol
SKU: T2741
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2741Cas No. 1405-86-3

Alias Glycyrrhizin

Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research.

Glycyrrhizic acid

🥰Excellent

Purity: 99.49%

Catalog No. T2741Alias GlycyrrhizinCas No. 1405-86-3

Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$42	In Stock
100 mg	$68	In Stock
500 mg	$198	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.49%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research.
Targets&IC50	MAO:0.16 μM, HEK293 cells:0.015 μM, Hepatocyte cells:82.4 μM, ECV-304 cells:> 119 μM, Raji cells:381 μM, MDCK cells:39.6 μM
In vitro	METHODS: MDCK cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was measured using MTT assay. RESULTS: Glycyrrhizic acid inhibited the growth of MDCK cells (EC50=15.2 µM). [1] METHODS: African green monkey Vero E6 cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was determined using MTT assay. RESULTS: Glycyrrhizic acid showed no inhibitory effect on the growth of Vero E6 cells (CC50>100 µM). [2]
In vivo	METHODS: To study the anti-inflammatory activity of Glycyrrhizic acid, Glycyrrhizic acid (50 mg/kg) was injected intraperitoneally to iodine-induced NOD.H-2h4 mice. RESULTS: Dihydroartemisinin significantly reduced the levels of TgAb, HMGB1, TNF-α, IL-6, and IL-1β in the mice and effectively alleviated thyroiditis in the mice. [3]
Synonyms	Glycyrrhizin

Chemical Properties

Molecular Weight	822.93
Formula	C₄₂H₆₂O₁₆
Cas No.	1405-86-3
Smiles	[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O[C@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O
Relative Density.	1.1442 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (113.01 mM), Sonication is recommended.

DMSO: 93 mg/mL (113.01 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 4.65 mg/mL (5.65 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2152 mL	6.0759 mL	12.1517 mL	60.7585 mL
5 mM	0.2430 mL	1.2152 mL	2.4303 mL	12.1517 mL
10 mM	0.1215 mL	0.6076 mL	1.2152 mL	6.0759 mL
20 mM	0.0608 mL	0.3038 mL	0.6076 mL	3.0379 mL
50 mM	0.0243 mL	0.1215 mL	0.2430 mL	1.2152 mL
100 mM	0.0122 mL	0.0608 mL	0.1215 mL	0.6076 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc