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Glycyrrhizic acid

Name: Glycyrrhizic acid
Brand: TargetMol
SKU: T2741
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2741Cas No. 1405-86-3

Alias Glycyrrhizin

Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research.

Glycyrrhizic acid

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Purity: 99.74%

Catalog No. T2741Alias GlycyrrhizinCas No. 1405-86-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$68	In Stock	In Stock
500 mg	$198	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Glycyrrhizic acid AI Summary

Glycyrrhizic acid exhibits a range of bioactivities across several assays and cell lines. It has shown hepatoprotective activity by providing 15.0% protection in aflatoxin B1-induced Hep G2 cells at 20 µg/ml and protecting against D-galactosamine/TNFalpha-induced cell death in mouse hepatocytes with various levels of protective activity at different concentrations. Additionally, it inhibits human 11beta-HSD1 and 11beta-HSD2 enzymes with potent IC50 values, suggesting its potential in modulating cortisol metabolism. Glycyrrhizic acid demonstrates nitric oxide scavenging activity in NOR1-induced human Chang liver cells and shows inhibitory effects on multiple human liver transporters and mouse liver microsome 11betaHSD1. It also exhibits cytotoxicity against human Raji cells, showing significant activity in TPA-induced EBV-early antigen activation. Moreover, Glycyrrhizic acid demonstrates antiviral activity against various viruses, including SARS-CoV-2 and Influenza A, and exhibits anti-inflammatory properties in TPA-induced ear edema in mice, among other bioactivities. Furthermore, it shows potential as an inhibitor of glycogen phosphorylase A, MRP2-mediated estradiol-17-beta-glucuronide transport, and hyaluronidase activity. These diverse bioactivities highlight the compound's therapeutic potential in hepatoprotection, inflammation, viral infections, and metabolic regulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research.
Targets&IC50	MAO:0.16 μM, HEK293 cells:0.015 μM, Hepatocyte cells:82.4 μM, Raji cells:381 μM, ECV-304 cells:> 119 μM, MDCK cells:39.6 μM
In vitro	METHODS: MDCK cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was measured using MTT assay. RESULTS: Glycyrrhizic acid inhibited the growth of MDCK cells (EC50=15.2 µM). [1] METHODS: African green monkey Vero E6 cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was determined using MTT assay. RESULTS: Glycyrrhizic acid showed no inhibitory effect on the growth of Vero E6 cells (CC50>100 µM). [2]
In vivo	METHODS: To study the anti-inflammatory activity of Glycyrrhizic acid, Glycyrrhizic acid (50 mg/kg) was injected intraperitoneally to iodine-induced NOD.H-2h4 mice. RESULTS: Dihydroartemisinin significantly reduced the levels of TgAb, HMGB1, TNF-α, IL-6, and IL-1β in the mice and effectively alleviated thyroiditis in the mice. [3]
Synonyms	Glycyrrhizin

Chemical Properties

Molecular Weight	822.93
Formula	C₄₂H₆₂O₁₆
Cas No.	1405-86-3
Smiles	[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O[C@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O
Relative Density.	1.1442 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (113.01 mM), Sonication is recommended.

DMSO: 257.5 mg/mL (312.91 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 4.65 mg/mL (5.65 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2152 mL	6.0759 mL	12.1517 mL	60.7585 mL
5 mM	0.2430 mL	1.2152 mL	2.4303 mL	12.1517 mL
10 mM	0.1215 mL	0.6076 mL	1.2152 mL	6.0759 mL
20 mM	0.0608 mL	0.3038 mL	0.6076 mL	3.0379 mL
50 mM	0.0243 mL	0.1215 mL	0.2430 mL	1.2152 mL
100 mM	0.0122 mL	0.0608 mL	0.1215 mL	0.6076 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc