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Anti-NCK1 Antibody (6Y736)
(Synonyms: SH2/SH3 Adaptor Protein NCK-α, SH2/SH3 Adaptor Protein NCK-Alpha, Nck-1, NCK1, NCK adaptor Protein 1, NCK, Cytoplasmic Protein NCK1) Copy Product Info
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Synonyms: SH2/SH3 Adaptor Protein NCK-α, SH2/SH3 Adaptor Protein NCK-Alpha, Nck-1, NCK1, NCK adaptor Protein 1, NCK, Cytoplasmic Protein NCK1
Catalog No. TMAC-02754 Copy Product Info
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Anti-NCK1 Antibody (6Y736) is a Rabbit antibody targeting NCK1. Anti-NCK1 Antibody (6Y736) can be used in FCM,ICC,IF,IHC,IP,WB.
Anti-NCK1 Antibody
(6Y736)
(6Y736)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $297 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-NCK1 Antibody (6Y736) is a Rabbit antibody targeting NCK1. Anti-NCK1 Antibody (6Y736) can be used in FCM,ICC,IF,IHC,IP,WB. |
| Synonyms | SH2/SH3 Adaptor Protein NCK-α, SH2/SH3 Adaptor Protein NCK-Alpha, Nck-1, NCK1, NCK adaptor Protein 1, NCK, Cytoplasmic Protein NCK1 |
| Ig Type | IgG |
| Clone | 6Y736 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; IP: 1:10-50; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 (NCKα) and NCK2 (NCKβ), which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. Specifically, overexpression of Nck1 in NIH/3T3 cells decreases DNA synthesis stimulated by EGF. Furthermore, the SH2 domain of NCK2 inhibits EGF- and PDGF-induced DNA synthesis. The SH3 domain of NCK binds a proline-rich domain on PAK, a known actin cytoskeleton regulator. The NCK protein thus mediates the interaction between PAK and RAC. The NCK2 protein binds human PDGFR-b (Tyr 1009); overexpression of Nck2 inhibits PDGF-induced membrane ruffling and lamellipod formation. Various growth factor receptors, cell surface antigens and adhesion molecules phosphorylate mammalian NCK1 and NCK2. The human NCK1 and NCK2 genes map to chromosomes 3q22.3 and 2q12.2, respectively. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 43/35 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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