DBCO-NH-(CH2)4COOH

Name: DBCO-NH-(CH2)4COOH
Brand: TargetMol
SKU: T17755
Rating: 4.5 (1 reviews)

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Catalog No. T17755Cas No. 2375193-74-9

DBCO-NH-(CH2)4COOH is a synthetic alkyl chain-based PROTAC linker, which finds utility in PROTAC synthesis[1].

DBCO-NH-(CH2)4COOH

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Catalog No. T17755Cas No. 2375193-74-9

DBCO-NH-(CH2)4COOH is a synthetic alkyl chain-based PROTAC linker, which finds utility in PROTAC synthesis[1].

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Product Introduction

Bioactivity

Description	DBCO-NH-(CH2)4COOH is a synthetic alkyl chain-based PROTAC linker, which finds utility in PROTAC synthesis[1].
In vitro	PROTACs consist of two ligands linked together; one binds to an E3 ubiquitin ligase, and the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	404.46
Formula	C₂₄H₂₄N₂O₄
Cas No.	2375193-74-9
Smiles	O=C(O)CCCCC(=O)NCCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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