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Oxfenicine
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Catalog No. T4785Cas No. 32462-30-9
Alias 4-Hydroxy-L-phenylglycine
Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistance.
Oxfenicine
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Purity: 99.22%
Catalog No. T4785Alias 4-Hydroxy-L-phenylglycineCas No. 32462-30-9
Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistance.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $40 | In Stock | In Stock | |
| 1 g | $56 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.22%
Appearance:Solid
Color:White
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Product Introduction
Oxfenicine AI Summary
Oxfenicine exhibits a range of bioactivities targeting different biological pathways and organisms. It demonstrates weak or no inhibitory effects on rat and human FAO, human CPT2, CPT1B, and CPT1A, with IC50 values exceeding 100,000 nM, and shows no significant cytotoxicity in human KB cells. Notably, it has potential anti-Ebola properties, exhibiting effectiveness in blocking virus entry with potencies ranging from 281.8 nM to 22.39 µM. It also shows activity in a cell-based assay targeting B-Galactocerebrosidase with a potency of 316.2 nM. Additionally, Oxfenicine inhibits the uptake of L-serine and D-serine, and potentiates NMDA receptor-mediated excitatory post-synaptic currents in rat hippocampal slices, indicating its role in modulating serine neurotransmission. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease by 35.77% at 20 µM and displays antiviral activity against SARS-CoV-2 in VERO-6 cells, with an inhibition of -0.07% at 10 µM after 48 hours. These diverse bioactivities suggest that Oxfenicine may have applications in antiviral therapies and neurological modulation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistance. |
| Synonyms | 4-Hydroxy-L-phenylglycine |
| Molecular Weight | 167.16 |
| Formula | C8H9NO3 |
| Cas No. | 32462-30-9 |
| Smiles | N[C@H](C(O)=O)c1ccc(O)cc1 |
| Relative Density. | 1.396 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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