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2'-Deoxyuridine

Name: 2'-Deoxyuridine
Brand: TargetMol
SKU: T1721
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1721Cas No. 951-78-0

Alias Uracil deoxyriboside, 2'-dU, 2-deoxyuridine

2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.

2'-Deoxyuridine

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Purity: 99.88%

Catalog No. T1721Alias Uracil deoxyriboside, 2'-dU, 2-deoxyuridineCas No. 951-78-0

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
200 mg	$48	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$89	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

2'-Deoxyuridine AI Summary

2'-Deoxyuridine exhibits significant bioactivity, particularly against herpes simplex virus type-1 (HSV-1) and various thymidine kinases. In vero cells, it shows antiviral potency with an IC50 value of 2.2 nM. This compound also inhibits [3H]-D-T phosphorylation catalyzed by HSV-1 thymidine kinase with an IC50 of 400.0 µM, and demonstrates a broad spectrum of kinase inhibition, affecting rat mitochondrial and cytoplasmic thymidine kinase by 74.0% and 90.0%, respectively. Additionally, it inhibits thymidine kinase and deoxycytidine kinase in L1210 cells with activity ranging from 65.0% to 93.0%, highlighting its potential to interfere with cellular processes. 2'-Deoxyuridine impacts nucleotide transport and metabolism by inhibiting the facilitated transport of [3N]-thymidine in murine erythrocytes with a Ki of 125,000 nM, and showing moderate phosphorylation activity on human TK1 (relative value 0.55) and high on human TK2 (relative value 1.0). It also competes with [6-3H]thymidine influx in mouse erythrocytes with a Ki of 130,000 nM, and substantially inhibits Escherichia coli thymidine phosphorylase activity, maintaining 83.0%-88.0% inhibition over 24 hours. In addition, 2'-Deoxyuridine exhibits cytotoxicity against human HuH7 cells with a CC50 greater than 200.0 µg/mL and shows competitive inhibition of HSV-1 pyrimidine deoxythymidine kinase (Ki 9500.0 nM). It interferes with the function of Escherichia coli thymidine kinase with a Ki of 290,000 nM and inhibits thymidine kinase in BHK21 (C13) cells at varying concentrations. The compound also shows antimicrobial activity against Streptococcus faecium (ED50 37.0 µM) and inhibition of recombinant Cryptosporidium hominis TS-DHFR activity by 5.3% at 500 µM. Overall, 2'-Deoxyuridine displays a diverse range of biological activities, making it a noteworthy candidate for further research in antiviral and antimicrobial therapy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.
Synonyms	Uracil deoxyriboside, 2'-dU, 2-deoxyuridine

Chemical Properties

Molecular Weight	228.2
Formula	C₉H₁₂N₂O₅
Cas No.	951-78-0
Smiles	O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=CC(=O)N1
Relative Density.	1.3705 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Limited solubility

DMSO: 100 mg/mL (438.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3821 mL	21.9106 mL	43.8212 mL	219.1060 mL
5 mM	0.8764 mL	4.3821 mL	8.7642 mL	43.8212 mL
10 mM	0.4382 mL	2.1911 mL	4.3821 mL	21.9106 mL
20 mM	0.2191 mL	1.0955 mL	2.1911 mL	10.9553 mL
50 mM	0.0876 mL	0.4382 mL	0.8764 mL	4.3821 mL
100 mM	0.0438 mL	0.2191 mL	0.4382 mL	2.1911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc