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Picroside II

Name: Picroside II
Brand: TargetMol
SKU: T2817
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2817Cas No. 39012-20-9

Alias Vanilloyl catalpol, 6-Vanilloylcatalpol

Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

Picroside II

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Purity: 99.83%

Catalog No. T2817Alias Vanilloyl catalpol, 6-VanilloylcatalpolCas No. 39012-20-9

Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$45	In Stock	In Stock
50 mg	$68	In Stock	In Stock
100 mg	$106	In Stock	In Stock
500 mg	$262	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Picroside II AI Summary

Picroside II displays a range of bioactivities across different biological assays. It demonstrates antihepatotoxic activity in Wistar rat hepatocytes against galactosamine-induced cytotoxicity, as measured by glutamic-pyruvic transaminase activity at various concentrations: 103.0% at 0.01 mg/ml, 101.0% at 0.1 mg/ml, and 78.0% at 1 mg/ml. The compound also induces cytotoxicity in these hepatocytes with increased activity levels (27.0 IU/L at 0.01 mg/ml, 28.0 IU/L at 0.1 mg/ml, and 40.0 IU/L at 1 mg/ml) after 30 hours. Additionally, Picroside II exhibits anti-inflammatory properties, reducing croton oil-induced ear swelling in BALB/c mice by 46.0% after 6 hours. It also shows antiviral activity against the hepatitis C virus (HCV) expressing E1E2 glycoprotein by inhibiting viral entry in Huh7 cells, with inhibition rates of 31.6% after 0.5 hours and 59.4% after 4 hours. Moreover, the compound has peroxynitrite scavenging activity, demonstrated by its IC50 value of 6000.0 nM in inhibiting DHR 123 oxidation in a fluorescence assay conducted in the presence of SIN-1..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
Synonyms	Vanilloyl catalpol, 6-Vanilloylcatalpol

Chemical Properties

Molecular Weight	512.46
Formula	C₂₃H₂₈O₁₃
Cas No.	39012-20-9
Smiles	COc1cc(ccc1O)C(=O)OC1C2OC2(CO)C2C1C=COC2OC1OC(CO)C(O)C(O)C1O
Relative Density.	1.66 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (487.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9514 mL	9.7569 mL	19.5137 mL	97.5686 mL
5 mM	0.3903 mL	1.9514 mL	3.9027 mL	19.5137 mL
10 mM	0.1951 mL	0.9757 mL	1.9514 mL	9.7569 mL
20 mM	0.0976 mL	0.4878 mL	0.9757 mL	4.8784 mL
50 mM	0.0390 mL	0.1951 mL	0.3903 mL	1.9514 mL
100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.9757 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc