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AU-15330

Name: AU-15330
Brand: TargetMol
SKU: T39954
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39954Cas No. 2380274-50-8

AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. [2]

AU-15330

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Purity: 99.62%

Catalog No. T39954Cas No. 2380274-50-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$347	In Stock	In Stock
10 mg	$538	In Stock	In Stock
25 mg	$868	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,590	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

ee:100%

Appearance:Solid

Color:White to Yellow

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. [2]
In vitro	METHODS: PCa cells (LNCaP, VCaP, 22RV1, and LAPC4) were treated with different concentrations of AU-15330 (0.1, 1 μM). RESULTS AU-15330 attenuated the growth of these cells and induced apoptotic cell death, while having no antiproliferative effect on benign or non-neoplastic prostate cells. [1]
In vivo	METHODS: AU-15330 (60 mg kg, i.v.) was administered to mice bearing VCaP and C4-2B castration-resistant tumor models, 3 days per week. RESULTS AU-15330 inhibited tumor growth in mice bearing VCaP and C4-2B castration-resistant tumor models without significant toxicity. [1]

Chemical Properties

Molecular Weight	755.93
Formula	C₃₉H₄₉N₉O₅S
Cas No.	2380274-50-8
Smiles	C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)C(C)(C)C)c1ccc(cc1)-c1scnc1C

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (334.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3229 mL	6.6144 mL	13.2287 mL	66.1437 mL
5 mM	0.2646 mL	1.3229 mL	2.6457 mL	13.2287 mL
10 mM	0.1323 mL	0.6614 mL	1.3229 mL	6.6144 mL
20 mM	0.0661 mL	0.3307 mL	0.6614 mL	3.3072 mL
50 mM	0.0265 mL	0.1323 mL	0.2646 mL	1.3229 mL
100 mM	0.0132 mL	0.0661 mL	0.1323 mL	0.6614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc