TT-OAD2 free base

Name: TT-OAD2 free base
Brand: TargetMol
SKU: T11406
Rating: 4.5 (1 reviews)

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Catalog No. T11406Cas No. 1246826-07-2

TT-OAD2 free base has the potential for diabetes treatment. TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM.

TT-OAD2 free base

😃Good

Catalog No. T11406Cas No. 1246826-07-2

TT-OAD2 free base has the potential for diabetes treatment. TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	TT-OAD2 free base has the potential for diabetes treatment. TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM.
Targets&IC50	GLP1 receptor:（EC50）5 nM
In vitro	TT-OAD2, at concentrations ranging from 0 to 10 μM, suppresses GLP-1- and oxyntomodulin-induced responses—including cAMP, calcium, pERK1/2, and β-arrestin—in a dose-dependent manner within HEK293A cells.
In vivo	TT-OAD2 ?treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice.

Chemical Properties

Molecular Weight	856.83
Formula	C₅₀H₄₇Cl₂N₃O₆
Cas No.	1246826-07-2
Smiles	[C@@H](CC)(N1[C@H](C(N[C@@H](CC2=CC=C(C=C2)C=3C(C)=C(C)N=CC3)C(O)=O)=O)CC=4C(C1)=CC5=C(C4)OC[C@@](O5)(C6=CC=C(OCC7=CC(Cl)=C(Cl)C=C7)C=C6)[H])C8=CC=CC=C8
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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