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CID-663143

Name: CID-663143
Brand: TargetMol
SKU: T23889
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23889Cas No. 578723-96-3

Alias CID663143

CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.

CID-663143

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Purity: 99.68%

Catalog No. T23889Alias CID663143Cas No. 578723-96-3

CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$166	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$350	In Stock	In Stock
100 mg	$470	-	In Stock
200 mg	$623	-	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

CID-663143 AI Summary

CID-663143 demonstrates significant bioactivity across a variety of cellular processes, indicating its potential as a pharmacologically active compound. It exhibits potent inhibition in multiple activities, including Lamin A splicing, luciferase translation, and aggregation formation in Huntington's disease model, with potencies ranging from 34.0 nM to 14125.4 nM. Additionally, it shows antagonistic activity against several cellular processes, such as the Hypoxia Response Element signaling pathway, Menin-MLL interaction, and Neuropeptide S receptor cAMP signal transduction, with potencies between 100.0 nM and 3981.1 nM. CID-663143 also affects CYP enzyme activity, with AC50 values exceeding 10 µM, and demonstrates efficacy as an inducer of DNA re-replication and synthetic lethality in tumor cells. Moreover, it inhibits various targets, including Hepatitis C Virus, TGF-β, and Lassa Virus, with potencies ranging from 23.1 nM to 35481.3 nM. Notably, it strongly inhibits the growth of human HT1080, BJeLR, and MCF10A cells, with an EC50 value of less than 100.0 nM in 24 hours according to alamar blue assay results. Overall, CID-663143's broad spectrum of bioactivities makes it a promising candidate for further drug discovery and development investigations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.
Synonyms	CID663143

Chemical Properties

Molecular Weight	366.44
Formula	C₁₉H₁₈N₄O₂S
Cas No.	578723-96-3
Smiles	O(C)C1=C(C=2N3C(=NN2)SCC(=N3)C4=CC=C(OCC)C=C4)C=CC=C1
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (150.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7290 mL	13.6448 mL	27.2896 mL	136.4480 mL
5 mM	0.5458 mL	2.7290 mL	5.4579 mL	27.2896 mL
10 mM	0.2729 mL	1.3645 mL	2.7290 mL	13.6448 mL
20 mM	0.1364 mL	0.6822 mL	1.3645 mL	6.8224 mL
50 mM	0.0546 mL	0.2729 mL	0.5458 mL	2.7290 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc