Powder: -20°C for 3 years | In solvent: -80°C for 1 year
USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 40.00 | |
5 mg | In stock | $ 94.00 | |
10 mg | In stock | $ 146.00 | |
25 mg | In stock | $ 282.00 | |
50 mg | In stock | $ 419.00 | |
100 mg | In stock | $ 596.00 |
Description | USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer. |
In vitro | USP22-IN-1 (USP22i-S02), as a USP22-specific inhibitor. (i)USP22i-S02 (10 ug/mL) inhibits Treg suppressive functions.[2] |
In vivo | USP22-IN-1 (USP22i-S02) (20 mg/kg; i.p.; twice a day for 5 days) inhibits tumor cell expression of PD-Ll, both of which enhance antitumor immune response. In addition, USP22i-S02 can directly inhibit tumor cell proliferation through USP22 suppression.[2] |
Molecular Weight | 338.41 |
Formula | C22H18N4 |
CAS No. | 309735-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 61.2 mg/mL (180.8 mM)
Ethanol: 2.7 mg/mL(8.0 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
USP22-IN-1 309735-96-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibitor inhibit