Shopping Cart

Your shopping cart is currently empty

NOTA

Name: NOTA
Brand: TargetMol
SKU: T40648
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T40648Cas No. 56491-86-2

NOTA is a multifunctional chelator capable of forming stable complexes with metal ions and is commonly used in radiopharmaceuticals, molecular imaging and targeted nuclear therapy.

NOTA

😃Good

Purity: 98.04%

Catalog No. T40648Cas No. 56491-86-2

NOTA is a multifunctional chelator capable of forming stable complexes with metal ions and is commonly used in radiopharmaceuticals, molecular imaging and targeted nuclear therapy.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	In Stock	In Stock
5 mg	$54	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$179	In Stock	In Stock
100 mg	$266	In Stock	In Stock
200 mg	$395	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.04%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	NOTA is a multifunctional chelator capable of forming stable complexes with metal ions and is commonly used in radiopharmaceuticals, molecular imaging and targeted nuclear therapy.
Targets&IC50	CXCR4 (Jurkat T cells):14.9  nM, αvβ3 integrin:27.9  nM
In vitro	[⁶⁴Cu]NOTA-pentixather showed high affinity for CXCR4 in Jurkat T cells (IC₅₀ = 14.9 ± 2.1 nM) and was efficiently internalized in Chem-1 cells stably expressing human CXCR4[1].[⁶⁸Ga]NOTA-RGD showed a high binding affinity for the αvβ₃ integrin (IC₅₀ = 27.9 ± 6.8 nM) in receptor binding assays, indicating effective targeting of integrin expression associated with angiogenesis[2].
In vivo	In SCID mice bearing Daudi lymphoma, intravenous injection of [⁶⁴Cu]NOTA-pentixather resulted in high tumor uptake (13.1 ± 1.5% ID/g at 1.5 h post-injection), exceeding uptake in all other organs[1].

Chemical Properties

Molecular Weight	303.31
Formula	C₁₂H₂₁N₃O₆
Cas No.	56491-86-2
Smiles	O=C(O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CC1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 110 mg/mL (362.67 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.2970 mL	16.4848 mL	32.9696 mL	164.8478 mL
5 mM	0.6594 mL	3.2970 mL	6.5939 mL	32.9696 mL
10 mM	0.3297 mL	1.6485 mL	3.2970 mL	16.4848 mL
20 mM	0.1648 mL	0.8242 mL	1.6485 mL	8.2424 mL
50 mM	0.0659 mL	0.3297 mL	0.6594 mL	3.2970 mL
100 mM	0.0330 mL	0.1648 mL	0.3297 mL	1.6485 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NOTA