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Nitroflurbiprofen

Name: Nitroflurbiprofen
Brand: TargetMol
SKU: T16329
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16329Cas No. 158836-71-6

Alias NO-flurbiprofen, Nitroxybutyl flurbiprofen, HCT 1206

Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

Nitroflurbiprofen

🥰Excellent

Purity: 99.88%

Catalog No. T16329Alias NO-flurbiprofen, Nitroxybutyl flurbiprofen, HCT 1206Cas No. 158836-71-6

Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$167	In Stock
10 mg	$257	In Stock
25 mg	$440	In Stock
50 mg	$592	In Stock
100 mg	$833	In Stock
200 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Purity:99.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
In vivo	Nitroflurbiprofen (45 mg/kg; i.p.) improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].
Synonyms	NO-flurbiprofen, Nitroxybutyl flurbiprofen, HCT 1206

Chemical Properties

Molecular Weight	361.36
Formula	C₁₉H₂₀FNO₅
Cas No.	158836-71-6
Smiles	CC(C(=O)OCCCCO[N+]([O-])=O)c1ccc(c(F)c1)-c1ccccc1
Relative Density.	1.214g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (152.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7673 mL	13.8366 mL	27.6732 mL	138.3662 mL
5 mM	0.5535 mL	2.7673 mL	5.5346 mL	27.6732 mL
10 mM	0.2767 mL	1.3837 mL	2.7673 mL	13.8366 mL
20 mM	0.1384 mL	0.6918 mL	1.3837 mL	6.9183 mL
50 mM	0.0553 mL	0.2767 mL	0.5535 mL	2.7673 mL
100 mM	0.0277 mL	0.1384 mL	0.2767 mL	1.3837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc