Shopping Cart
- Remove All
- Your shopping cart is currently empty
Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | TBD | In Stock | |
5 mg | TBD | 35 days | |
10 mg | TBD | 35 days |
Description | Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis. |
In vitro | Punicic acid at 10 μM for 4 min strongly inhibits TNF-α-induced excessive ROS production in neutrophils, without affecting ROS production triggered by fMLP or Phorbol 12-myristate 13-acetate [1]. Punicic acid at concentrations ranging from 0 to 40 μM for 30 min reduces TNF-α-induced p47phox phosphorylation starting at 10 μM [1]. Punicic acid at 10 μM for 30 min inhibits NADPH oxidase activation in neutrophils [1]. Punicic acid at 0 to 40 μM for 48 h shows a concentration-dependent anti-proliferative effect on MDA-ERα7 and MDA-wt cells [2]. Punicic acid at 40 μM for 48 h induces apoptosis in MDA-ERα7 and MDA-wt cells and increases the percentage of cells in the G2/M phase. This apoptotic effect is completely blocked by the presence of 20 μM α-tocotrienol[2]. The anti-proliferative effect of Punicic acid at 5 to 80 μM for 48 h is partially inhibited by 4 μM BIM in MDA-ERα7 and MDA-wt cells [2]. |
In vivo | Oral administration of Punicic acid (400 μg, once daily for ten days) significantly alleviated colonic damage induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in male Wistar rats, resulting in only mild inflammatory infiltration and scattered mucosal erosions [2]. |
Alias | Trichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic Acid |
Molecular Weight | 278.43 |
Formula | C18H30O2 |
Cas No. | 544-72-9 |
Smiles | C(C/C=C\C=C\C=C/CCCC)CCCCCC(O)=O |
Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (287.33 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.