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Punicic acid

Name: Punicic acid
Brand: TargetMol
SKU: T78472
Rating: 4.5 (1 reviews)

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Catalog No. T78472Cas No. 544-72-9

Alias Trichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic Acid

Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis.

Punicic acid

😃Good

Catalog No. T78472Alias Trichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic AcidCas No. 544-72-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$287	35 days	35 days
5 mg	$1,200	35 days	35 days
10 mg	$2,080	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis.
In vitro	Punicic acid at 10 μM for 4 min strongly inhibits TNF-α-induced excessive ROS production in neutrophils, without affecting ROS production triggered by fMLP or Phorbol 12-myristate 13-acetate [1]. Punicic acid at concentrations ranging from 0 to 40 μM for 30 min reduces TNF-α-induced p47phox phosphorylation starting at 10 μM [1]. Punicic acid at 10 μM for 30 min inhibits NADPH oxidase activation in neutrophils [1]. Punicic acid at 0 to 40 μM for 48 h shows a concentration-dependent anti-proliferative effect on MDA-ERα7 and MDA-wt cells [2]. Punicic acid at 40 μM for 48 h induces apoptosis in MDA-ERα7 and MDA-wt cells and increases the percentage of cells in the G2/M phase. This apoptotic effect is completely blocked by the presence of 20 μM α-tocotrienol[2]. The anti-proliferative effect of Punicic acid at 5 to 80 μM for 48 h is partially inhibited by 4 μM BIM in MDA-ERα7 and MDA-wt cells [2].
In vivo	Oral administration of Punicic acid (400 μg, once daily for ten days) significantly alleviated colonic damage induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in male Wistar rats, resulting in only mild inflammatory infiltration and scattered mucosal erosions [2].
Synonyms	Trichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic Acid

Chemical Properties

Molecular Weight	278.43
Formula	C₁₈H₃₀O₂
Cas No.	544-72-9
Smiles	C(C/C=C\C=C\C=C/CCCC)CCCCCC(O)=O

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (287.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (11.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5916 mL	17.9578 mL	35.9157 mL	179.5784 mL
5 mM	0.7183 mL	3.5916 mL	7.1831 mL	35.9157 mL
10 mM	0.3592 mL	1.7958 mL	3.5916 mL	17.9578 mL
20 mM	0.1796 mL	0.8979 mL	1.7958 mL	8.9789 mL
50 mM	0.0718 mL	0.3592 mL	0.7183 mL	3.5916 mL
100 mM	0.0359 mL	0.1796 mL	0.3592 mL	1.7958 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc