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Punicic acid

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Catalog No. T78472Cas No. 544-72-9
Alias Trichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic Acid

Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis.

Punicic acid

Punicic acid

😃Good
Catalog No. T78472Alias Trichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic AcidCas No. 544-72-9
Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis.
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1 mgTBDIn Stock
5 mgTBD35 days
10 mgTBD35 days
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Concentration:10.0 mg/mL
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Product Introduction

Bioactivity
Description
Punicic acid (Trichosanic acid) is a naturally occurring conjugated linolenic acid and polyunsaturated fatty acid that is anti-obesity and anti-diabetic through activation of PPARα, PPARβ, PPARγ, and inhibition of NF-κB; anti-inflammatory through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX); improves neuroinflammation; and prevention of osteoporosis.
In vitro
Punicic acid at 10 μM for 4 min strongly inhibits TNF-α-induced excessive ROS production in neutrophils, without affecting ROS production triggered by fMLP or Phorbol 12-myristate 13-acetate [1].
Punicic acid at concentrations ranging from 0 to 40 μM for 30 min reduces TNF-α-induced p47phox phosphorylation starting at 10 μM [1].
Punicic acid at 10 μM for 30 min inhibits NADPH oxidase activation in neutrophils [1].
Punicic acid at 0 to 40 μM for 48 h shows a concentration-dependent anti-proliferative effect on MDA-ERα7 and MDA-wt cells [2].
Punicic acid at 40 μM for 48 h induces apoptosis in MDA-ERα7 and MDA-wt cells and increases the percentage of cells in the G2/M phase. This apoptotic effect is completely blocked by the presence of 20 μM α-tocotrienol[2].
The anti-proliferative effect of Punicic acid at 5 to 80 μM for 48 h is partially inhibited by 4 μM BIM in MDA-ERα7 and MDA-wt cells [2].
In vivo
Oral administration of Punicic acid (400 μg, once daily for ten days) significantly alleviated colonic damage induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in male Wistar rats, resulting in only mild inflammatory infiltration and scattered mucosal erosions [2].
AliasTrichosanic acid, 9Z,11E,13Z-octadecatrienoic acid, 9(Z),11(E),13(Z)-Octadecatrienoic Acid
Chemical Properties
Molecular Weight278.43
FormulaC18H30O2
Cas No.544-72-9
SmilesC(C/C=C\C=C\C=C/CCCC)CCCCCC(O)=O
Storage & Solubility Information
Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (287.33 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5916 mL17.9578 mL35.9157 mL179.5784 mL
5 mM0.7183 mL3.5916 mL7.1831 mL35.9157 mL
10 mM0.3592 mL1.7958 mL3.5916 mL17.9578 mL
20 mM0.1796 mL0.8979 mL1.7958 mL8.9789 mL
50 mM0.0718 mL0.3592 mL0.7183 mL3.5916 mL
100 mM0.0359 mL0.1796 mL0.3592 mL1.7958 mL

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