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(S,R,S)-AHPC-C10-NH2 dihydrochloride

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Catalog No. T18661Cas No. 2341796-75-4
Alias VH032-linker 10, VH032-C10-NH2 dihydrochloride, VH032 amide-alkylC10-amine

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate, incorporating an (S,R,S)-AHPC-based VHL ligand and a linker[1].

(S,R,S)-AHPC-C10-NH2 dihydrochloride
Other Forms of (S,R,S)-AHPC-C10-NH2 dihydrochloride:
(S,R,S)-AHPC-C10-NH2T178812341796-74-3
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(S,R,S)-AHPC-C10-NH2 dihydrochloride

😃Good
Catalog No. T18661Alias VH032-linker 10, VH032-C10-NH2 dihydrochloride, VH032 amide-alkylC10-amineCas No. 2341796-75-4
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate, incorporating an (S,R,S)-AHPC-based VHL ligand and a linker[1].
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25 mg$55835 days35 days
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate, incorporating an (S,R,S)-AHPC-based VHL ligand and a linker[1].
In vitro
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
SynonymsVH032-linker 10, VH032-C10-NH2 dihydrochloride, VH032 amide-alkylC10-amine
Chemical Properties
Molecular Weight686.78
FormulaC33H53Cl2N5O4S
Cas No.2341796-75-4
SmilesCC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCN)O.Cl.Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 200 mg/mL (291.21 mM), Sonication is recommended.
DMSO: 200 mg/mL (291.21 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.81 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.4561 mL7.2804 mL14.5607 mL72.8035 mL
5 mM0.2912 mL1.4561 mL2.9121 mL14.5607 mL
10 mM0.1456 mL0.7280 mL1.4561 mL7.2804 mL
20 mM0.0728 mL0.3640 mL0.7280 mL3.6402 mL
50 mM0.0291 mL0.1456 mL0.2912 mL1.4561 mL
100 mM0.0146 mL0.0728 mL0.1456 mL0.7280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VHLVH032-C10-NH2 DihydrochlorideVH032-C10-NH2PROTACLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 Ligase Ligand-Linker ConjugatesBETAHPC-C10-NH2 DihydrochlorideAHPC-C10-NH2AHPC(S,R,S)-AHPC-C-10-NH2 dihydrochloride(S,R,S)AHPCC10NH2 dihydrochloride(S,R,S) AHPC C10 NH2 dihydrochloride
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