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Anti-BST2 Antibody (2B626)
😃Good
Catalog No. TMAY-02577
Alias GREG, DAMP-1, CD317, C87040, Bst-2, bone marrow stromal cell antigen 2, 2310015I10Rik
Anti-BST2 Antibody (2B626) is a Mouse antibody targeting BST2. Anti-BST2 Antibody (2B626) can be used in IHC-P.
Anti-BST2 Antibody (2B626)
Anti-BST2 Antibody (2B626)
😃Good
Catalog No. TMAY-02577Alias GREG, DAMP-1, CD317, C87040, Bst-2, bone marrow stromal cell antigen 2, 2310015I10Rik
Anti-BST2 Antibody (2B626) is a Mouse antibody targeting BST2. Anti-BST2 Antibody (2B626) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | GREG, DAMP-1, CD317, C87040, Bst-2, bone marrow stromal cell antigen 2, 2310015I10Rik |
| Ig Type | Mouse IgG1 |
| Clone | 2B626 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human BST2 in human liver with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BST2 (rh BST2; TMPY-03235; Q10589; Asn49-Ser160). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling. BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC. IFN (interferon)-induced BST2 recruits the E3 ubiquitin ligase MARCH8 to catalyze the K27-linked ubiquitination of MAVS for CALCOCO2-directed autophagic degradation, hence inhibiting DDX58-mediated type I interferon signaling through a negative feedback loop. BST2 is a host protein with dual functions in response to viral infections: it traps newly assembled enveloped virions at the plasma membrane in infected cells, and it induces NF-κB activity, especially in the context of retroviral assembly. BST2 may induce or amplify proinflammatory signaling during Ebola virus infection, potentially contributing to the dysregulated cytokine response that is a hallmark of Ebola virus disease. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human BST2 Protein (TMPY-03235) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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