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Anti-SMURF2 Antibody (2L792)
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Catalog No. TMAC-03810
Alias SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2
Anti-SMURF2 Antibody (2L792) is a Rabbit antibody targeting SMURF2. Anti-SMURF2 Antibody (2L792) can be used in WB.
Anti-SMURF2 Antibody (2L792)
Anti-SMURF2 Antibody (2L792)
😃Good
Catalog No. TMAC-03810Alias SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2
Anti-SMURF2 Antibody (2L792) is a Rabbit antibody targeting SMURF2. Anti-SMURF2 Antibody (2L792) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-SMURF2 Antibody (2L792) is a Rabbit antibody targeting SMURF2. Anti-SMURF2 Antibody (2L792) can be used in WB. |
| Synonyms | SMURF2, SMAD-specific E3 ubiquitin-protein ligase 2, SMAD ubiquitination regulatory factor 2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, E3 ubiquitin-protein ligase SMURF2 |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of SMURF 2 on A431 cell using anti-SMURF 2 antibody at 1/200 dilution. |
| Application | |
| Recommended Dose | WB: 1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Smurf1 and Smurf2 (SMAD ubiquitination regulatory factor-1 and 2) are members of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway, which targets proteins for degradation by the 26S proteasome. Within the Ub pathway, the E3 ligases specifically catalyze the transfer of Ub from the Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated SMADs specific to the BMP pathway in order to trigger their ubiquitination and degradation. Smurf2 interacts with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3, but not Smad4. Although Smurf2 localizes to the nucleus, binding to Smad7 induces its export and its recruitment to the activated TGFβ receptor, where it causes degradation of Smad7. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 86 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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