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Nithiamide

Name: Nithiamide
Brand: TargetMol
SKU: T1108
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1108Cas No. 140-40-9

Alias CL-5279, Aminitrozole

Nithiamide (CL-5279) is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis.

Nithiamide

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Purity: 99.85%

Catalog No. T1108Alias CL-5279, AminitrozoleCas No. 140-40-9

Nithiamide (CL-5279) is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Nithiamide (CL-5279) is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis.
In vivo	For both sensitive and metronidazole-resistant strains of Trichomonas vaginalis, Nithiamide showed sustained potent activity under both aerobic and anaerobic conditions.
Synonyms	CL-5279, Aminitrozole

Chemical Properties

Molecular Weight	187.18
Formula	C₅H₅N₃O₃S
Cas No.	140-40-9
Smiles	CC(=O)NC1=NC=C(S1)[N+]([O-])=O
Relative Density.	1.598g/cm3
Color	Yellow
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 35 mg/mL (186.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3425 mL	26.7123 mL	53.4245 mL	267.1226 mL
5 mM	1.0685 mL	5.3425 mL	10.6849 mL	53.4245 mL
10 mM	0.5342 mL	2.6712 mL	5.3425 mL	26.7123 mL
20 mM	0.2671 mL	1.3356 mL	2.6712 mL	13.3561 mL
50 mM	0.1068 mL	0.5342 mL	1.0685 mL	5.3425 mL
100 mM	0.0534 mL	0.2671 mL	0.5342 mL	2.6712 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc