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Thymectacin

Name: Thymectacin
Brand: TargetMol
SKU: T24881
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24881Cas No. 232925-18-7

Alias NB-1011, NB1011, NB 1011

Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.

Thymectacin

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Purity: 99.49%

Catalog No. T24881Alias NB-1011, NB1011, NB 1011Cas No. 232925-18-7

Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$293	In Stock	In Stock
10 mg	$475	In Stock	In Stock
25 mg	$953	In Stock	In Stock
50 mg	$1,530	In Stock	In Stock
100 mg	$1,980	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.49%

Appearance:Solid

Color:White

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COA CNMR HNMR LCMS PNMR

Product Introduction

Bioactivity

Description	Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.
Targets&IC50	MDA-MB-231 cells:79 μM (EC50), PC3 cells:155 μM (EC50), HT115 cells:245 μM (EC50)
In vitro	The main clinical candidate, Thymectacin, showed only moderate activity in vitro, with EC50 values ranging from 79-245 μM in our assay. However, relatively minor structural adjustments resulted in a significant increase in potency.MDA-MB 231 EC50=79 μM, HT 115 EC50=245 μM, and PC-3 EC50=155 μM. [1]
Synonyms	NB-1011, NB1011, NB 1011

Chemical Properties

Molecular Weight	574.32
Formula	C₂₁H₂₅BrN₃O₉P
Cas No.	232925-18-7
Smiles	O=C1N(C=C(/C=C/Br)C(=O)N1)[C@@H]2O[C@H](COP(OC3=CC=CC=C3)(N[C@H](C(OC)=O)C)=O)[C@@H](O)C2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL(139.30 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7412 mL	8.7059 mL	17.4119 mL	87.0595 mL
5 mM	0.3482 mL	1.7412 mL	3.4824 mL	17.4119 mL
10 mM	0.1741 mL	0.8706 mL	1.7412 mL	8.7059 mL
20 mM	0.0871 mL	0.4353 mL	0.8706 mL	4.3530 mL
50 mM	0.0348 mL	0.1741 mL	0.3482 mL	1.7412 mL
100 mM	0.0174 mL	0.0871 mL	0.1741 mL	0.8706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc