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Valecobulin hydrochloride

Name: Valecobulin hydrochloride
Brand: TargetMol
SKU: T13278
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13278Cas No. 1240321-53-2

Alias CKD-516 hydrochloride

Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans.

Valecobulin hydrochloride

🥰Excellent

Purity: 99.52%

Catalog No. T13278Alias CKD-516 hydrochlorideCas No. 1240321-53-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$173	In Stock	In Stock
10 mg	$273	In Stock	In Stock
25 mg	$452	In Stock	In Stock
50 mg	$636	In Stock	In Stock
100 mg	$858	In Stock	In Stock
200 mg	$1,150	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$218	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans.
In vivo	METHODS: Nude mice carrying human colonic HCT116 and human colonic overexpression of the P-gp transporter HCT15 were treated with Valecobulin hydrochloride (CKD-516 hydrochloride) (5 mg/kg and 10 mg/kg, intraperitoneal injection, Q4D 4). RESULTS The IR of Valecobulin hydrochloride (CKD-516 hydrochloride) in HCT116 nude mice was 36% and 65%, respectively, and tumor growth was significantly inhibited in a dose-dependent manner; Valecobulin hydrochloride (CKD-516 hydrochloride) also showed resistance to MDR The potent antitumor activity of positive cell lines (HCT15), with IRs of 12% and 5%, respectively. [2]
Synonyms	CKD-516 hydrochloride

Chemical Properties

Molecular Weight	573.06
Formula	C₂₆H₂₉ClN₆O₅S
Cas No.	1240321-53-2
Smiles	Cl.COc1cc(cc(OC)c1OC)C(=O)c1ccc(cc1-n1cncn1)-c1csc(NC(=O)[C@@H](N)C(C)C)n1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (218.13 mM), Sonication is recommended.

H2O: 50 mg/mL (87.25 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7450 mL	8.7251 mL	17.4502 mL	87.2509 mL
5 mM	0.3490 mL	1.7450 mL	3.4900 mL	17.4502 mL
10 mM	0.1745 mL	0.8725 mL	1.7450 mL	8.7251 mL
20 mM	0.0873 mL	0.4363 mL	0.8725 mL	4.3625 mL
50 mM	0.0349 mL	0.1745 mL	0.3490 mL	1.7450 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0175 mL	0.0873 mL	0.1745 mL	0.8725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc