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Mutant IDH1-IN-1

Name: Mutant IDH1-IN-1
Brand: TargetMol
SKU: T2043
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2043Cas No. 1355326-21-4

Alias IDH1-IN-1

Mutant IDH1-IN-1 is a potent inhibitor of the mutant IDH1 R132 h, exhibiting an IC50 of less than 0.1 μM.

Mutant IDH1-IN-1

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Purity: 99.49%

Catalog No. T2043Alias IDH1-IN-1Cas No. 1355326-21-4

Mutant IDH1-IN-1 is a potent inhibitor of the mutant IDH1 R132 h, exhibiting an IC50 of less than 0.1 μM.

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$65	In Stock
10 mg	$100	In Stock
25 mg	$193	In Stock
50 mg	$276	In Stock
100 mg	$403	In Stock
200 mg	$545	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.49%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mutant IDH1-IN-1 is a potent inhibitor of the mutant IDH1 R132 h, exhibiting an IC50 of less than 0.1 μM.
Targets&IC50	IDH1 (R132H):< 0.1 μM.
Synonyms	IDH1-IN-1

Chemical Properties

Molecular Weight	498.59
Formula	C₃₀H₃₁FN₄O₂
Cas No.	1355326-21-4
Smiles	Cc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (120.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0057 mL	10.0283 mL	20.0566 mL	100.2828 mL
5 mM	0.4011 mL	2.0057 mL	4.0113 mL	20.0566 mL
10 mM	0.2006 mL	1.0028 mL	2.0057 mL	10.0283 mL
20 mM	0.1003 mL	0.5014 mL	1.0028 mL	5.0141 mL
50 mM	0.0401 mL	0.2006 mL	0.4011 mL	2.0057 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc