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PROTAC EGFR degrader 10

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Catalog No. T88273Cas No. 3034244-56-6

PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.

PROTAC EGFR degrader 10

PROTAC EGFR degrader 10

😃Good
Catalog No. T88273Cas No. 3034244-56-6
PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.
Targets&IC50
CRBN-DDB1:37 nM (Ki)
Chemical Properties
Molecular Weight973.62
FormulaC49H65ClN10O7S
Cas No.3034244-56-6
SmilesO=C1NC(=O)C(C2=CC=C(C=C2)N3CCC(OCCN4CCN(CC4)C5CCN(C6=CC(OC)=C(C=C6CC)NC7=NC=C(Cl)C(=N7)NC8=CC=C(OC)C=C8N(C)S(=O)(=O)C)CC5)CC3)CC1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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