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RO-9187

Name: RO-9187
Brand: TargetMol
SKU: T16774
Rating: 4.5 (1 reviews)

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Catalog No. T16774Cas No. 876708-03-1

RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).

RO-9187

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Catalog No. T16774Cas No. 876708-03-1

RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$113	5 days	5 days
5 mg	$236	5 days	5 days
50 mg	$721	6-8 weeks	6-8 weeks
100 mg	$997	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$218	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
Targets&IC50	HCV:171 nM
In vitro	RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1].
In vivo	Plasma exposures of RO-9187 in rats increase dose-dependently from 10 to 2000 mg/kg after oral administration. Plasma concentrations of RO-9187 (1.4 and 26 μM) are achieved in rats and dogs at the 10 mg/kg dose, respectively, with concentrations reaching up to 57 μM in rats at 2000 mg/kg/day[1].

Chemical Properties

Molecular Weight	284.23
Formula	C₉H₁₂N₆O₅
Cas No.	876708-03-1
Smiles	Nc1ccn([C@@H]2O[C@@](CO)(N=[N+]=[N-])[C@@H](O)[C@@H]2O)c(=O)n1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 7.14 mg/mL (25.12 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.5183 mL	17.5914 mL	35.1828 mL	175.9139 mL
5 mM	0.7037 mL	3.5183 mL	7.0366 mL	35.1828 mL
10 mM	0.3518 mL	1.7591 mL	3.5183 mL	17.5914 mL
20 mM	0.1759 mL	0.8796 mL	1.7591 mL	8.7957 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc