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Z-YVAD-FMK

Name: Z-YVAD-FMK
Brand: TargetMol
SKU: TP1466
Price: 170 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1466Cas No. 210344-97-1

AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.

Z-YVAD-FMK

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Purity: 98.00%

Catalog No. TP1466Cas No. 210344-97-1

AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$170	In Stock	In Stock
2 mg	$243	In Stock	In Stock
5 mg	$392	In Stock	In Stock
10 mg	$609	In Stock	In Stock
25 mg	$938	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$548	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.00%

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.
In vitro	Z-YVAD-FMK (100 μM; 24 hours) significantly mitigated butyrate-induced growth inhibition in Caco-2 cells.

Chemical Properties

Molecular Weight	630.66
Formula	C₃₁H₃₉FN₄O₉
Cas No.	210344-97-1
Smiles	COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(C)C)C(=O)CF
Relative Density.	1.261 g/cm3 (Predicted)
Sequence	Z-Tyr-Val-Ala-Asp-FMK
Sequence Short	Z-YVAD-FMK

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (396.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5856 mL	7.9282 mL	15.8564 mL	79.2820 mL
5 mM	0.3171 mL	1.5856 mL	3.1713 mL	15.8564 mL
10 mM	0.1586 mL	0.7928 mL	1.5856 mL	7.9282 mL
20 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9641 mL
50 mM	0.0317 mL	0.1586 mL	0.3171 mL	1.5856 mL
100 mM	0.0159 mL	0.0793 mL	0.1586 mL	0.7928 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc