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Z-YVAD-FMK

Name: Z-YVAD-FMK
Brand: TargetMol
SKU: TP1466
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1466Cas No. 210344-97-1

AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.

Z-YVAD-FMK

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Purity: 98.00%

Catalog No. TP1466Cas No. 210344-97-1

AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.

Pack Size	Price	Availability
1 mg	$179	In Stock
2 mg	$257	In Stock
5 mg	$413	In Stock
10 mg	$641	In Stock
25 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$577	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.00%

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COA HNMR

Product Introduction

Bioactivity

Description	AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.
In vitro	Z-YVAD-FMK (100 μM; 24 hours) significantly mitigated butyrate-induced growth inhibition in Caco-2 cells.

Chemical Properties

Molecular Weight	630.66
Formula	C₃₁H₃₉FN₄O₉
Cas No.	210344-97-1
Smiles	COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(C)C)C(=O)CF
Relative Density.	1.261 g/cm3 (Predicted)
Color	White
Appearance	Solid
Sequence	Z-Tyr-Val-Ala-Asp-FMK
Sequence Short	Z-YVAD-FMK

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (396.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5856 mL	7.9282 mL	15.8564 mL	79.2820 mL
5 mM	0.3171 mL	1.5856 mL	3.1713 mL	15.8564 mL
10 mM	0.1586 mL	0.7928 mL	1.5856 mL	7.9282 mL
20 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9641 mL
50 mM	0.0317 mL	0.1586 mL	0.3171 mL	1.5856 mL
100 mM	0.0159 mL	0.0793 mL	0.1586 mL	0.7928 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc