Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Nav1.1 activator 1

😃Good
Catalog No. T12179Cas No. 2332897-85-3

Nav1.1 activator 1 (compound 4) is an effective Nav1.1 agonist with blood-brain barrier permeability, exhibiting significant selectivity for Nav1.2, Nav1.5, and Nav1.6. It increases the decay time constant of Nav1.1 at 0.03 μM current and can be used for studying central nervous system disorders.

Nav1.1 activator 1

Nav1.1 activator 1

😃Good
Catalog No. T12179Cas No. 2332897-85-3
Nav1.1 activator 1 (compound 4) is an effective Nav1.1 agonist with blood-brain barrier permeability, exhibiting significant selectivity for Nav1.2, Nav1.5, and Nav1.6. It increases the decay time constant of Nav1.1 at 0.03 μM current and can be used for studying central nervous system disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$9546-8 weeks6-8 weeks
50 mg$1,2406-8 weeks6-8 weeks
100 mg$1,9906-8 weeks6-8 weeks
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
Nav1.1 activator 1 (compound 4) is an effective Nav1.1 agonist with blood-brain barrier permeability, exhibiting significant selectivity for Nav1.2, Nav1.5, and Nav1.6. It increases the decay time constant of Nav1.1 at 0.03 μM current and can be used for studying central nervous system disorders.
In vivo
Methods: In pharmacokinetic analysis, exposure was measured 1 hour after a single 30 mg/kg intraperitoneal injection of Nav1.1 activator 1 in mice.
Results: Nav1.1 activator 1 achieved sufficient brain exposure (193 ng/g), indicating blood-brain barrier (BBB) penetration.
Chemical Properties
Molecular Weight440.46
FormulaC24H23F3N4O
Cas No.2332897-85-3
SmilesC(NC=1C=CC(C(C)C)=NC1)(=O)C=2C(=CC=NC2N3C[C@@H](F)CC3)C4=C(F)C=CC(F)=C4
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (454.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2704 mL11.3518 mL22.7035 mL113.5177 mL
5 mM0.4541 mL2.2704 mL4.5407 mL22.7035 mL
10 mM0.2270 mL1.1352 mL2.2704 mL11.3518 mL
20 mM0.1135 mL0.5676 mL1.1352 mL5.6759 mL
50 mM0.0454 mL0.2270 mL0.4541 mL2.2704 mL
100 mM0.0227 mL0.1135 mL0.2270 mL1.1352 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nav-1.1 activator 1Nav1.1 activator 1
Related Tags: buy Nav1.1 activator 1 | purchase Nav1.1 activator 1 | Nav1.1 activator 1 cost | order Nav1.1 activator 1 | Nav1.1 activator 1 chemical structure | Nav1.1 activator 1 in vivo | Nav1.1 activator 1 formula | Nav1.1 activator 1 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.