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Nav1.1 activator 1

Name: Nav1.1 activator 1
Brand: TargetMol
SKU: T12179
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12179Cas No. 2332897-85-3

Nav1.1 activator 1 (compound 4) is an effective Nav1.1 agonist with blood-brain barrier permeability, exhibiting significant selectivity for Nav1.2, Nav1.5, and Nav1.6. It increases the decay time constant of Nav1.1 at 0.03 μM current and can be used for studying central nervous system disorders.

Nav1.1 activator 1

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Purity: 99.99%

Catalog No. T12179Cas No. 2332897-85-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$255	-	In Stock
10 mg	$396	-	In Stock
25 mg	$791	-	In Stock
50 mg	$1,230	-	In Stock
100 mg	$1,990	-	In Stock
1 mL x 10 mM (in DMSO)	$279	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nav1.1 activator 1 (compound 4) is an effective Nav1.1 agonist with blood-brain barrier permeability, exhibiting significant selectivity for Nav1.2, Nav1.5, and Nav1.6. It increases the decay time constant of Nav1.1 at 0.03 μM current and can be used for studying central nervous system disorders.
In vivo	Methods: In pharmacokinetic analysis, exposure was measured 1 hour after a single 30 mg/kg intraperitoneal injection of Nav1.1 activator 1 in mice. Results: Nav1.1 activator 1 achieved sufficient brain exposure (193 ng/g), indicating blood-brain barrier (BBB) penetration.

Chemical Properties

Molecular Weight	440.46
Formula	C₂₄H₂₃F₃N₄O
Cas No.	2332897-85-3
Smiles	C(NC=1C=CC(C(C)C)=NC1)(=O)C=2C(=CC=NC2N3C[C@@H](F)CC3)C4=C(F)C=CC(F)=C4
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (454.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2704 mL	11.3518 mL	22.7035 mL	113.5177 mL
5 mM	0.4541 mL	2.2704 mL	4.5407 mL	22.7035 mL
10 mM	0.2270 mL	1.1352 mL	2.2704 mL	11.3518 mL
20 mM	0.1135 mL	0.5676 mL	1.1352 mL	5.6759 mL
50 mM	0.0454 mL	0.2270 mL	0.4541 mL	2.2704 mL
100 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc