Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Atumelnant

Name: Atumelnant
Brand: TargetMol
SKU: T86091
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T86091Cas No. 2392970-97-5

Alias CRN04894, CRN 04894

Atumelnant (CRN04894) is a selective and potent MC2R antagonist that inhibits ACTH-stimulated corticosterone secretion in a dose-dependent manner for the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).

Atumelnant

Copy Product Info

😃Good

Purity: 98.41%

Catalog No. T86091Alias CRN04894, CRN 04894Cas No. 2392970-97-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.41%

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Atumelnant (CRN04894) is a selective and potent MC2R antagonist that inhibits ACTH-stimulated corticosterone secretion in a dose-dependent manner for the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).
Targets&IC50	MC2R (rat):0.23 nM (KB), MC2R (human):0.34 nM (KB)
In vitro	Atumelnant is an orally potent MC2R antagonist that inhibits corticosterone secretion induced by adrenocorticotropic hormone (ACTH) stimulation in a rat model. Atumelnant has a binding constant (KB value) of 0.34 nM for human MC2R and 0.23 nM for rat MC2R. [1]
In vivo	In an ACTH-stimulated male rat model, single oral administration of Atumelnant at 3 mg/kg and 30 mg/kg significantly and dose-dependently reduced corticosterone secretion levels. [1]
Synonyms	CRN04894, CRN 04894

Chemical Properties

Molecular Weight	613.71
Formula	C₃₃H₄₂F₃N₅O₃
Cas No.	2392970-97-5
Smiles	C(=O)(C1(C(F)(F)F)CCC1)N2C[C@@H](CC)N(CC2)C3=C(C(N[C@H]4C5CCN(C4)CC5)=O)N=C(C=C3)C6=C(OCC)C=CC=C6

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (130.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6294 mL	8.1472 mL	16.2943 mL	81.4717 mL
5 mM	0.3259 mL	1.6294 mL	3.2589 mL	16.2943 mL
10 mM	0.1629 mL	0.8147 mL	1.6294 mL	8.1472 mL
20 mM	0.0815 mL	0.4074 mL	0.8147 mL	4.0736 mL
50 mM	0.0326 mL	0.1629 mL	0.3259 mL	1.6294 mL
100 mM	0.0163 mL	0.0815 mL	0.1629 mL	0.8147 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc