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Bisindolylmaleimide XI hydrochloride
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Catalog No. T36228Cas No. 145333-02-4
Alias Ro 32-0432
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ (IC50 = 9/28/31/37/108 nM).
Bisindolylmaleimide XI hydrochloride
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Purity: 99.45%
Catalog No. T36228Alias Ro 32-0432Cas No. 145333-02-4
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ (IC50 = 9/28/31/37/108 nM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $215 | - | In Stock | |
| 5 mg | $536 | - | In Stock | |
| 10 mg | $773 | - | In Stock | |
| 25 mg | $1,190 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.45%
Appearance:Solid
Color:Red
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ (IC50 = 9/28/31/37/108 nM). |
| Targets&IC50 | PKCβI:28 nM, PKCε:108 nM, PKCγ:37 nM, PKCβII:31 nM, PKCα:9 nM |
| In vitro | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) significantly inhibits IL-2 secretion, IL-2 receptor expression, and proliferative capacity in Homo sapiens peripheral T cells. These T cells were activated by phorbol ester combined with phytohemagglutinin or anti-CD3 antibody stimulation. However, this compound shows no significant inhibitory effect on IL-2-induced proliferation in T cells that have already been activated and express IL-2 receptors. For the influenza peptide antigen HA 307-319-specific Homo sapiens T cell clone (HA27), the proliferative response occurring after co-culture with antigen-pulsed autologous antigen-presenting cells can also be effectively suppressed by Bisindolylmaleimide XI hydrochloride [2]. Bisindolylmaleimide XI hydrochloride (1 μM) intervention in retinal progenitor cells (RPCs) reduces the apoptosis ratio by 21% through inhibition of PKC activity [3]. |
| In vivo | Oral administration of Bisindolylmaleimide XI hydrochloride significantly inhibits phorbol ester-induced subsequent edema reactions in rats. Bisindolylmaleimide XI hydrochloride can suppress various T cell-mediated physiological immune responses, with typical examples including host rejection reaction against grafts and secondary paw swelling symptoms observed in adjuvant-induced arthritis models [2]. |
| Synonyms | Ro 32-0432 |
| Molecular Weight | 489.01 |
| Formula | C28H29ClN4O2 |
| Cas No. | 145333-02-4 |
| Smiles | Cl.O=C1NC(=O)C(=C1C2=CN(C=3C=CC=CC23)C)C=4C=5C=CC=CC5N6C4CC(CN(C)C)CC6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (8.18 mM), Sonication is recommended. Methanol: Soluble, Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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