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CDK4/6-IN-7

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Catalog No. T61738Cas No. 2649120-20-5

CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].

CDK4/6-IN-7

CDK4/6-IN-7

😃Good
Catalog No. T61738Cas No. 2649120-20-5
CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].
Targets&IC50
CDK4:1.58 nM, CDK6:4.09 nM
In vitro
CDK4/6-IN-7 (compound 7c) impairs MCF-7 cell viability with an IC₅₀ value of 0.92 μM after 48 hours of exposure to concentrations ranging from 0.1 to 656.1 μM, as observed in a cell proliferation assay [1].
In vivo
CDK4/6-IN-7 (compound 7c), when administered orally at 50 mg/kg daily for seven days, significantly inhibits tumor growth with a 57.68% inhibition rate in MCF-7 tumor-bearing female nude mice (aged 5 weeks), demonstrating both efficacy and tolerability.
Chemical Properties
Molecular Weight387.82
FormulaC18H18ClN5O3
Cas No.2649120-20-5
SmilesC(NC=1C=CC=NC1)(=O)[C@@H]2N(C(NNC(=O)C3=C(Cl)C=CC=C3)=O)CCC2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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