Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1]. |
In vitro | CDK4/6-IN-7 (compound 7c), at concentrations ranging from 0.1 to 656.1 μM over 48 hours, impairs MCF-7 cell viability, demonstrating an IC 50 value of 0.92 μM [1]. This effect was observed in a cell proliferation assay conducted on MCF-7 cells, which were exposed to increasing concentrations of 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, to 656.1 μM for a period of 48 hours, resulting in inhibited cell growth with the IC 50 determined at 0.92 μM. |
In vivo | CDK4/6-IN-7 (compound 7c) administered orally at a dosage of 50 mg/kg daily for seven days significantly inhibits tumor growth in MCF-7 tumor-bearing female nude mice aged 5 weeks. The treatment resulted in a tumor inhibition rate of 57.68% and was well-tolerated, demonstrating its efficacy in reducing the growth rates of MCF-7 tumors in mice. |
Molecular Weight | 387.82 |
Formula | C18H18ClN5O3 |
CAS No. | 2649120-20-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CDK4/6-IN-7 2649120-20-5 inhibitor inhibit