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N-Oxalylglycine

Name: N-Oxalylglycine
Brand: TargetMol
SKU: T21634
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21634Cas No. 5262-39-5

Alias Oxalylglycine

N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.

N-Oxalylglycine

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Purity: 99.23%

Catalog No. T21634Alias OxalylglycineCas No. 5262-39-5

N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$62	In Stock	In Stock
200 mg	$83	In Stock	-
500 mg	$146	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.23%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

N-Oxalylglycine AI Summary

N-Oxalylglycine exhibits broad inhibitory bioactivities against a range of enzymes and cellular targets, particularly those involved in hydroxylation and demethylation processes. Notable among these, it inhibits human prolyl 4-hydroxylase with an IC50 value of 2890.0 nM and a Ki value of 540.0 nM. It also strongly inhibits human recombinant PHD2 with varying Ki and IC50 values depending on conditions, including 8000.0 nM and 18500.0 nM respectively. Additionally, it targets other enzymes such as FIH (IC50 of 50000.0 nM) and JMJD2C (IC50 of 500000.0 nM). The compound has been shown to affect prolyl hydroxylase and demethylase families, including KDM4A, KDM4C, PHD1, and PHD2, with IC50 values ranging from 2100.0 nM to 6200.0 nM for PHD enzymes. Furthermore, N-Oxalylglycine demonstrates inhibitory activity against TET enzymes (IC50 of 80000.0 nM for general TET and 19700.0 nM for TET2). The compound is also noted for its antiviral activity against SARS-CoV-2 and its ability to destabilize human recombinant PHD2, in addition to showing varying potencies against other biochemical targets and enzyme activities. This compound's diverse range of activities suggests potential therapeutic applications in modulation of enzyme activities involved in DNA/RNA modifications and cellular oxygen sensing pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.
Synonyms	Oxalylglycine

Chemical Properties

Molecular Weight	147.09
Formula	C₄H₅NO₅
Cas No.	5262-39-5
Smiles	OC(=O)CNC(=O)C(O)=O
Relative Density.	1.638 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (169.96 mM), Sonication is recommended.

DMSO: < 1.47 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.7986 mL	33.9928 mL	67.9856 mL	339.9279 mL
5 mM	1.3597 mL	6.7986 mL	13.5971 mL	67.9856 mL
10 mM	0.6799 mL	3.3993 mL	6.7986 mL	33.9928 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.3399 mL	1.6996 mL	3.3993 mL	16.9964 mL
50 mM	0.1360 mL	0.6799 mL	1.3597 mL	6.7986 mL
100 mM	0.0680 mL	0.3399 mL	0.6799 mL	3.3993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc