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Clorsulon

Name: Clorsulon
Brand: TargetMol
SKU: T1137
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1137Cas No. 60200-06-8

Alias MK401, L631529

Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep.

Clorsulon

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Purity: 99.87%

Catalog No. T1137Alias MK401, L631529Cas No. 60200-06-8

Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$87	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep.
Targets&IC50	ATP:0.29 mM(ki), 3-phosphoglycorate:0.29 mM(ki)
In vitro	In sheep and calves, a single administration of Clorsulon (15 mg/kg) effectively induces damage to the cortical and intestinal tissues of the liver flukes, thereby expelling immature liver flukes from the host organism.
In vivo	Clorsulon is a competitive inhibitor (Ki=0.29 mM) of both 3-phosphoglycerate and ATP, capable of suppressing glucose utilization and the formation of acetate and propionate.
Synonyms	MK401, L631529

Chemical Properties

Molecular Weight	380.66
Formula	C₈H₈Cl₃N₃O₄S₂
Cas No.	60200-06-8
Smiles	C(=C(Cl)Cl)(Cl)C1=C(S(N)(=O)=O)C=C(S(N)(=O)=O)C(N)=C1
Relative Density.	1.8 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 7 mg/mL (18.39 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (186.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6270 mL	13.1351 mL	26.2702 mL	131.3508 mL
5 mM	0.5254 mL	2.6270 mL	5.2540 mL	26.2702 mL
10 mM	0.2627 mL	1.3135 mL	2.6270 mL	13.1351 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1314 mL	0.6568 mL	1.3135 mL	6.5675 mL
50 mM	0.0525 mL	0.2627 mL	0.5254 mL	2.6270 mL
100 mM	0.0263 mL	0.1314 mL	0.2627 mL	1.3135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc