LY309887

Name: LY309887
Brand: TargetMol
SKU: T15813
Rating: 4.5 (1 reviews)

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Catalog No. T15813Cas No. 127228-54-0

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM) with antitumor activity.

LY309887

😃Good

Catalog No. T15813Cas No. 127228-54-0

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM) with antitumor activity.

Pack Size	Price	Availability
25 mg	$1,400	10-14 weeks
50 mg	$1,820	10-14 weeks
100 mg	$2,810	10-14 weeks

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Product Introduction

Bioactivity

Description	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM) with antitumor activity.
Targets&IC50	GARFT:(ki)6.5 nM, FRα:1.78 nM(ki), FRβ:18.2 nM(ki)
In vitro	LY309887 is significantly cytotoxic against the human leukemia cell line CCRF-CEM (IC50: 9.9 nM). LY309887 also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM, and 18.2 nM, respectively) .
In vivo	In mice bearing C3H mammary cancer cells, LY309887 (3 mg/kg-100 mg/kg, i.p.) displays complete inhibition on the tumor growth.

Chemical Properties

Molecular Weight	449.48
Formula	C₁₉H₂₃N₅O₆S
Cas No.	127228-54-0
Relative Density.	1.68 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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