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ME1111

Name: ME1111
Brand: TargetMol
SKU: T16033
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16033Cas No. 1391758-52-3

ME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes. Notably proficient in penetrating human nails, it is utilized in onychomycosis research.

ME1111

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Purity: 99.91%

Catalog No. T16033Cas No. 1391758-52-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$100	-	In Stock
10 mg	$151	-	In Stock
25 mg	$272	-	In Stock
50 mg	$375	-	In Stock
100 mg	$533	-	In Stock
200 mg	$691	-	In Stock
1 mL x 10 mM (in DMSO)	$111	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:Cyan

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

ME1111 (0.125, 0.0625 μg/mL; 4, 8, 12 h) inhibits T. mentagrophytes TIMM 2789 (MICs: 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively).[2]
ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines.[2]

Chemical Properties

Molecular Weight	202.25
Formula	C₁₂H₁₄N₂O
Cas No.	1391758-52-3
Smiles	Cc1cc(C)n(n1)-c1ccc(C)cc1O
Relative Density.	1.13 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (444.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (16.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9444 mL	24.7219 mL	49.4438 mL	247.2188 mL
5 mM	0.9889 mL	4.9444 mL	9.8888 mL	49.4438 mL
10 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
20 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
50 mM	0.0989 mL	0.4944 mL	0.9889 mL	4.9444 mL
100 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc