CDK2-IN-47

Name: CDK2-IN-47
Brand: TargetMol
SKU: T213069
Rating: 4.5 (1 reviews)

Catalog No. T213069 Copy Product Info

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CDK2-IN-47 is a potent CDK2 inhibitor with an IC50 of 0.21 μM. It demonstrates strong anticancer activity against MCF-7, HCT-116, and MGC-803 cell lines. CDK2-IN-47 effectively induces G1 cell cycle arrest, retinoblastoma protein (Rb) dephosphorylation, and significant apoptosis. It is applicable for research on breast, colorectal, and gastric cancers.

CDK2-IN-47

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Catalog No. T213069

CDK2-IN-47

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	CDK2-IN-47 is a potent CDK2 inhibitor with an IC50 of 0.21 μM. It demonstrates strong anticancer activity against MCF-7, HCT-116, and MGC-803 cell lines. CDK2-IN-47 effectively induces G1 cell cycle arrest, retinoblastoma protein (Rb) dephosphorylation, and significant apoptosis. It is applicable for research on breast, colorectal, and gastric cancers.
Targets&IC50	CDK2:0.21 μM
In vitro	CDK2-IN-47 (Compound 14c) exhibits potent anticancer activity against the cell lines MCF-7 (IC50 = 0.7 μM), HCT-116 (IC50 = 1.1 μM), and MGC-803 (IC50 = 1.5 μM), while showing significant selectivity towards non-cancerous HEK293 cells (SI = 22.4). At a concentration of 0.7 μM, CDK2-IN-47 induces significant apoptosis in MCF-7 cells after 48 hours and causes G0/G1 phase cell cycle arrest after 24 hours. Moreover, it leads to a marked reduction in Ser807/811 site Rb phosphorylation in MCF-7 cells. Additionally, CDK2-IN-47 demonstrates high metabolic stability in human liver microsomes, with a half-life (t½) of 68.5 minutes and a clearance rate (CLint) of 8.5 mL/min/kg.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc