Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 413.00 | |
25 mg | In stock | $ 748.00 | |
50 mg | In stock | $ 1,160.00 | |
100 mg | In stock | $ 1,620.00 | |
500 mg | In stock | $ 3,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 283.00 |
Description | OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells. |
Targets&IC50 | A549 cells:0.67μM |
In vitro | OTS186935 FA that showed enzymatic IC50 of 6.49 nM and A549 cell growth inhibitory effect with IC50 of 0.67 μM[1]. |
In vivo | Immunocompromised mice carrying MDA-MB-231 were intravenously administered with OTS186935 or vehicle control at a dose of 10 mg/kg once daily for 14 days. On the 14th day, a tumor growth inhibition (TGI) of 42.6% was observed[1]. |
Synonyms | OTS186935 FA(2093400-18-9 Free base) |
Molecular Weight | 509.98 |
Formula | C26H28ClN5O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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OTS186935 FA Chromatin/Epigenetic Histone Methyltransferase OTS186935 FA(2093400-18-9 Free base) OTS186935FA(2093400189Freebase) inhibitor inhibit