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IBS008738

Name: IBS008738
Brand: TargetMol
SKU: T40481
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40481Cas No. 385425-03-6

Alias IBS-008738

IBS008738 is an effective TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription, promotes muscle repair in injury models, and prevents muscle atrophy.

IBS008738

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Purity: 99.44%

Catalog No. T40481Alias IBS-008738Cas No. 385425-03-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$124	-	In Stock
10 mg	$207	-	In Stock
25 mg	$456	-	In Stock
50 mg	$788	-	In Stock
1 mL x 10 mM (in DMSO)	$136	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	IBS008738 is an effective TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription, promotes muscle repair in injury models, and prevents muscle atrophy.
In vitro	IBS008738 promotes myogenesis in C2C12 cells within the concentration range of 1-10 μM, with the most significant effect observed at 10 μM. The compound exhibits optimal efficacy when administered during the initial 24 hours of differentiation, markedly enhancing the expression of myogenin and MyoD [1]. IBS008738 facilitates myogenesis and muscle repair by stabilizing TAZ and strengthening the interaction between TAZ and MyoD, thereby promoting the transcription of myogenesis-related genes [1]. Treatment with IBS008738 (10 μM, 24 hours) elevates interleukin-10 (IL-10) levels in C2C12 cells [2].
In vivo	In the mouse model of myocardial toxin-induced muscular injury, IBS008738 (3 nmol) promoted muscle regeneration and increased the number of central nucleated muscle fibers [1]. In the dexamethasone-induced muscular atrophy mouse model, IBS008738 (30 μM, 100 μL) prevented muscular atrophy and increased the cross-sectional area of muscle fibers and protein synthesis [1]. In the traumatic brain injury (TBI) mouse model, IBS008738 (30 μM, 100 μL, intramuscular injection, immediately and on day 2 after TBI) significantly reduced the expression of TNFα and IL-6 but markedly increased the expression of IL-10 [2].
Synonyms	IBS-008738

Chemical Properties

Molecular Weight	374.44
Formula	C₂₂H₂₂N₄O₂
Cas No.	385425-03-6
Smiles	O=C(C=1C=CC=CC1)C2=C(N=CN2C3=CC=C(C=C3)C)N=CN4CCOCC4
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (106.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.5 mg/mL (4.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6707 mL	13.3533 mL	26.7065 mL	133.5327 mL
5 mM	0.5341 mL	2.6707 mL	5.3413 mL	26.7065 mL
10 mM	0.2671 mL	1.3353 mL	2.6707 mL	13.3533 mL
20 mM	0.1335 mL	0.6677 mL	1.3353 mL	6.6766 mL
50 mM	0.0534 mL	0.2671 mL	0.5341 mL	2.6707 mL
100 mM	0.0267 mL	0.1335 mL	0.2671 mL	1.3353 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc