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5α-Hydroxycostic acid, a naturally occurring sesquiterpene, inhibits choroidal neovascularization in rats through dual signaling pathways mediated by VEGF/VEGFR and Ang2/Tie2 (angiopoietin 2), and exhibits anti-inflammatory and anti-angiogenic effects on human breast cancer cells

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $99 | - | In Stock |
| Description | 5α-Hydroxycostic acid, a naturally occurring sesquiterpene, inhibits choroidal neovascularization in rats through dual signaling pathways mediated by VEGF/VEGFR and Ang2/Tie2 (angiopoietin 2), and exhibits anti-inflammatory and anti-angiogenic effects on human breast cancer cells |
| In vitro | Methods: RCSEC cells were treated with 5α-Hydroxycostic acid (25, 50, 100 μM, 48 hours) and the inducing factor VEGF164 (30 μM) was added. Cell viability was measured by CCK8. Results: The drug had a significant effect on cell viability at concentrations above 100 μM. [1] |
| Synonyms | 5 alpha-Hydroxycostic acid |
| Molecular Weight | 250.33 |
| Formula | C15H22O3 |
| Cas No. | 132185-83-2 |
| Smiles | O[C@]12[C@@](C)(CC[C@@H](C(C(O)=O)=C)C1)CCCC2=C |
| Relative Density. | 1.12 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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