Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polzastobart (JTX-8064), a humanized IgG4 monoclonal antibody, functions as an antagonist selectively targeting LILRB2. It inhibits its interaction with both classical and non-classical MHC I molecules. By preventing LILRB2 from binding to HLA-A/B and HLA-G, which are associated with immunotolerance in cancer cells, Polzastobart promotes the production of pro-inflammatory cytokines in macrophages, thereby serving as a macrophage immune checkpoint inhibitor [1].
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Description | Polzastobart (JTX-8064), a humanized IgG4 monoclonal antibody, functions as an antagonist selectively targeting LILRB2. It inhibits its interaction with both classical and non-classical MHC I molecules. By preventing LILRB2 from binding to HLA-A/B and HLA-G, which are associated with immunotolerance in cancer cells, Polzastobart promotes the production of pro-inflammatory cytokines in macrophages, thereby serving as a macrophage immune checkpoint inhibitor [1]. |
Synonyms | JTX 8064 |
Molecular Weight | N/A |
CAS No. | 2640981-19-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Polzastobart 2640981-19-5 JTX 8064 inhibitor inhibit