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PAOPA

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Catalog No. T23121Cas No. 114200-31-6

PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.

PAOPA

PAOPA

🥰Excellent
Catalog No. T23121Cas No. 114200-31-6
PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.
Pack SizePriceAvailabilityQuantity
1 mg$148In Stock
5 mg$372In Stock
10 mg$612In Stock
25 mg$1,290In Stock
50 mg$1,980In Stock
100 mg$2,790In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:>99.99%
ee:99.84%
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COA CSFC HNMR LCMS

Product Introduction

Bioactivity
Description
PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.
In vitro
10 μM PAOPA, treated for 1.5 hr increased striatal expression of GRK2 in D2/eYFP-labeled cells and promoted expression of arrestin-3, phosphorylated ERK1 and ERK2.
10 μM PAOPA, treated for 48 h then promoted internalization of D2 receptors in D2/eYFP-labeled cells. [1]
In vivo
In chronic administration, intraperitoneal injection of 1 mg/kg PAOPA once daily for 45 days enhanced D2 receptor modulation and up-regulated the expression of downstream molecules (e.g., GRK2, arrestin-3, and phosphorylated ERK 1/2) in mice. [1]
Chemical Properties
Molecular Weight254.29
FormulaC11H18N4O3
Cas No.114200-31-6
SmilesN(C(=O)[C@@H]1CCCN1)[C@H]2C(=O)N(CC(N)=O)CC2
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (176.96 mM), Sonication is recommended.
H2O: <25.43 mg/mL, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9325 mL19.6626 mL39.3252 mL196.6259 mL
5 mM0.7865 mL3.9325 mL7.8650 mL39.3252 mL
10 mM0.3933 mL1.9663 mL3.9325 mL19.6626 mL
20 mM0.1966 mL0.9831 mL1.9663 mL9.8313 mL
50 mM0.0787 mL0.3933 mL0.7865 mL3.9325 mL
100 mM0.0393 mL0.1966 mL0.3933 mL1.9663 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PAOPADopamineReceptorDopamine ReceptorD2
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