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PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,120 | In Stock | |
50 mg | $2,780 | In Stock | |
100 mg | $3,700 | In Stock |
Description | PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction. |
In vitro | 10 μM PAOPA, treated for 1.5 hr increased striatal expression of GRK2 in D2/eYFP-labeled cells and promoted expression of arrestin-3, phosphorylated ERK1 and ERK2. 10 μM PAOPA, treated for 48 h then promoted internalization of D2 receptors in D2/eYFP-labeled cells. [1] |
In vivo | In chronic administration, intraperitoneal injection of 1 mg/kg PAOPA once daily for 45 days enhanced D2 receptor modulation and up-regulated the expression of downstream molecules (e.g., GRK2, arrestin-3, and phosphorylated ERK 1/2) in mice. [1] |
Molecular Weight | 254.29 |
Formula | C11H18N4O3 |
Cas No. | 114200-31-6 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (39.33 mM), Sonication is recommended. H2O: <25.43 mg/mL | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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