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PAOPA

Name: PAOPA
Brand: TargetMol
SKU: T23121
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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PAOPA belongs to natural product derivatives and serves as an allosteric modulator of the dopamine D2 receptor, possessing the characteristic of promoting binding between high-affinity D2 receptors and agonists. This compound finds application in preclinical studies for schizophrenia and extrapyramidal dysfunction, effectively alleviating behavioral and biochemical abnormalities in rodent models.

Cas No. 114200-31-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$148	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$612	In Stock	In Stock
25 mg	$1,290	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,790	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:>99.99%

ee:99.84%

Appearance:Solid

Color:White to Yellow

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	PAOPA belongs to natural product derivatives and serves as an allosteric modulator of the dopamine D2 receptor, possessing the characteristic of promoting binding between high-affinity D2 receptors and agonists. This compound finds application in preclinical studies for schizophrenia and extrapyramidal dysfunction, effectively alleviating behavioral and biochemical abnormalities in rodent models.
In vitro	Methods: D2/eYFP-labeled cells were treated with 10 μM PAOPA for 1.5 hours and 48 hours, respectively. GRK2, arrestin-3, phosphorylated ERK1/2 expression, and D2 receptor internalization were subsequently detected. Results: Treatment for 1.5 hours increased striatal GRK2 expression and promoted the expression of arrestin-3, p-ERK1, and p-ERK2; treatment for 48 hours facilitated D2 receptor internalization. [1]
In vivo	Methods: In mice, PAOPA (1 mg/kg) was administered via intraperitoneal injection once daily for 45 consecutive days to evaluate its effects on D2 receptors and downstream molecules. Results: Chronic administration induced D2 receptor modulation and increased the expression of downstream molecules GRK2, arrestin-3, and ERK1/2. [1]

Chemical Properties

Molecular Weight	254.29
Formula	C₁₁H₁₈N₄O₃
Cas No.	114200-31-6
Smiles	N(C(=O)[C@@H]1CCCN1)[C@H]2C(=O)N(CC(N)=O)CC2
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (176.96 mM), Sonication is recommended.

H2O: <25.43 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9325 mL	19.6626 mL	39.3252 mL	196.6259 mL
5 mM	0.7865 mL	3.9325 mL	7.8650 mL	39.3252 mL
10 mM	0.3933 mL	1.9663 mL	3.9325 mL	19.6626 mL
20 mM	0.1966 mL	0.9831 mL	1.9663 mL	9.8313 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9325 mL
100 mM	0.0393 mL	0.1966 mL	0.3933 mL	1.9663 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc