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LDC4297 hydrochloride

Name: LDC4297 hydrochloride
Brand: TargetMol
SKU: T72385
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72385Cas No. 2319747-14-1

LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.

LDC4297 hydrochloride

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Catalog No. T72385Cas No. 2319747-14-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.
Targets&IC50	HSV2:0.27 μM (EC50), HSV1:0.02 μM (EC50), CDK7:0.13 nM, HIV-1 (NL4-3):1.04 μM (EC50), GPCMV:0.05 μM (EC50, MCMV:0.07 μM (EC50), poxvirus:0.77 μM (EC50), Fibroblasts (human):4.5 μM (GI50), Influenza A:0.99 μM (EC50), HCMV:0.02 μM (EC50), VZV:0.06 μM (EC50), HHV-6A:0.04 μM (EC50), HCMV:24.5 nM (EC50), HIV-1 (4LIG7):1.13 μM (EC50), HAdV-2:0.25 μM (EC50), EBV:1.21 μM (EC50)
In vitro	LDC4297 hydrochloride is a highly selective CDK7 inhibitor with an IC50 value of 0.13 nM. LDC4297 hydrochloride (0-10 μM, 6 days treatment) dose-dependently inhibited HCMV replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride (20 μM, 12-96 hours treatment) exhibited anti-HCMV activity by multiple mechanisms including blocking virus-induced Rb phosphorylation. LDC4297 hydrochloride (20 μM, 12-96 hrs) demonstrated anti-HCMV activity through multiple mechanisms, including blocking virus-induced Rb phosphorylation. [1] LDC4297 hydrochloride (0-10 μM, treated for 4 days) exhibited anti-proliferative effects on primary cultures of human-derived fibroblasts (HFF) with a GI50 value of 4.5 μM. [1] LDC4297 hydrochloride (concentration range 0-10 μM, treatment for 7 days) exhibited a broad spectrum of antiviral effects against a wide range of viruses, including HCMV, GPCMV, MCMV, HHV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, poxvirus, HIV-1 (nl4-3), HIV-1 ( 4LIG7) and influenza A virus, with corresponding EC50 values of 0.02 μM, 0.05 μM, 0.07 μM, 0.04 μM, 0.02 μM, 0.27 μM, 0.06 μM, 1.21 μM, 0.25 μM, 0.77 μM, 1.04 μM, 1.13 μM, and 0.99 μM, respectively. [1]
In vivo	LDC4297 hydrochloride (100 mg/kg, single oral dose) showed promising pharmacokinetic properties. [1]

Chemical Properties

Molecular Weight	468.98
Formula	C₂₃H₂₉ClN₈O
Cas No.	2319747-14-1
Smiles	Cl.N1=CC=CN1C=2C=CC=CC2CNC3=NC(=NC4=C(C=NN34)C(C)C)OC5CNCCC5

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (170.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1323 mL	10.6614 mL	21.3229 mL	106.6144 mL
5 mM	0.4265 mL	2.1323 mL	4.2646 mL	21.3229 mL
10 mM	0.2132 mL	1.0661 mL	2.1323 mL	10.6614 mL
20 mM	0.1066 mL	0.5331 mL	1.0661 mL	5.3307 mL
50 mM	0.0426 mL	0.2132 mL	0.4265 mL	2.1323 mL
100 mM	0.0213 mL	0.1066 mL	0.2132 mL	1.0661 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc