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HPN-01

Name: HPN-01
Brand: TargetMol
SKU: T11573
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11573Cas No. 928655-63-4

Alias HPN01, HPN 01

HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders.

HPN-01

🥰Excellent

Purity: 98.17%

Catalog No. T11573Alias HPN01, HPN 01Cas No. 928655-63-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$147	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$787	-	In Stock
50 mg	$1,180	-	In Stock
100 mg	$1,780	-	In Stock
200 mg	$2,430	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.17%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders.
Targets&IC50	IKKε:4.8(pIC50), IKKα:6.4(pIC50), IKKβ:7(pIC50), IKKα:6.4 (pIC50), IKKβ:7 (pIC50), IKKε:4.8 (pIC50)
In vitro	HPN-01 could inhibit the expression of SREBP-1 and SREBP-2 in human primary hepatocytes, and the IC50 values were 1.71 and 3.43, respectively. It is commonly used in the study of nonalcoholic fatty liver disease (NAFLD)[1].
Synonyms	HPN01, HPN 01

Chemical Properties

Molecular Weight	401.87
Formula	C₁₉H₁₆ClN₃O₃S
Cas No.	928655-63-4
Smiles	NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1
Relative Density.	1.425 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (199.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4884 mL	12.4418 mL	24.8837 mL	124.4183 mL
5 mM	0.4977 mL	2.4884 mL	4.9767 mL	24.8837 mL
10 mM	0.2488 mL	1.2442 mL	2.4884 mL	12.4418 mL
20 mM	0.1244 mL	0.6221 mL	1.2442 mL	6.2209 mL
50 mM	0.0498 mL	0.2488 mL	0.4977 mL	2.4884 mL
100 mM	0.0249 mL	0.1244 mL	0.2488 mL	1.2442 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc