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PRL-3 Inhibitor I

Name: PRL-3 Inhibitor I
Brand: TargetMol
SKU: T22136
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22136Cas No. 893449-38-2

Alias PRL-3 Inhibitor, BR-1

PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.

PRL-3 Inhibitor I

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Purity: 98.11%

Catalog No. T22136Alias PRL-3 Inhibitor, BR-1Cas No. 893449-38-2

PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$108	In Stock	In Stock
100 mg	$179	In Stock	In Stock
500 mg	$453	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.11%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.
Targets&IC50	PRL3:0.9 μM (IC50)
In vitro	PRL-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of DiFMUP by PRL-3 and strongly suppressed the activity of PRL-3 phosphatase in PRL-3 overexpressing DLD-1 colon tumor cells [DLD-1 (PRL-3)]. Also, PRL-3 inhibitor dose-dependently blocked the migration of DLD-1 (PRL-3) cells, however, it did not inhibit the proliferation of DLD-1(PRL-3) cells, suggesting that PRL-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity
Synonyms	PRL-3 Inhibitor, BR-1

Chemical Properties

Molecular Weight	485.21
Formula	C₁₇H₁₁Br₂NO₂S₂
Cas No.	893449-38-2
Smiles	Brc1ccc(OCc2ccccc2Br)c(\C=C2/SC(=S)NC2=O)c1
Relative Density.	1.85 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (113.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0610 mL	10.3048 mL	20.6096 mL	103.0482 mL
5 mM	0.4122 mL	2.0610 mL	4.1219 mL	20.6096 mL
10 mM	0.2061 mL	1.0305 mL	2.0610 mL	10.3048 mL
20 mM	0.1030 mL	0.5152 mL	1.0305 mL	5.1524 mL
50 mM	0.0412 mL	0.2061 mL	0.4122 mL	2.0610 mL
100 mM	0.0206 mL	0.1030 mL	0.2061 mL	1.0305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc