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PRL-3 Inhibitor I

Name: PRL-3 Inhibitor I
Brand: TargetMol
SKU: T22136
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22136Cas No. 893449-38-2

Alias PRL-3 Inhibitor, BR-1

PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.

PRL-3 Inhibitor I

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Purity: 98.11%

Catalog No. T22136Alias PRL-3 Inhibitor, BR-1Cas No. 893449-38-2

PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$49	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$221	In Stock	In Stock
200 mg	$332	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.11%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.
Targets&IC50	PRL3:0.9 μM (IC50)
In vitro	PRL-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of DiFMUP by PRL-3 and strongly suppressed the activity of PRL-3 phosphatase in PRL-3 overexpressing DLD-1 colon tumor cells [DLD-1 (PRL-3)]. Also, PRL-3 inhibitor dose-dependently blocked the migration of DLD-1 (PRL-3) cells, however, it did not inhibit the proliferation of DLD-1(PRL-3) cells, suggesting that PRL-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity
Synonyms	PRL-3 Inhibitor, BR-1

Chemical Properties

Molecular Weight	485.21
Formula	C₁₇H₁₁Br₂NO₂S₂
Cas No.	893449-38-2
Smiles	Brc1ccc(OCc2ccccc2Br)c(\C=C2/SC(=S)NC2=O)c1
Relative Density.	1.85 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (113.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0610 mL	10.3048 mL	20.6096 mL	103.0482 mL
5 mM	0.4122 mL	2.0610 mL	4.1219 mL	20.6096 mL
10 mM	0.2061 mL	1.0305 mL	2.0610 mL	10.3048 mL
20 mM	0.1030 mL	0.5152 mL	1.0305 mL	5.1524 mL
50 mM	0.0412 mL	0.2061 mL	0.4122 mL	2.0610 mL
100 mM	0.0206 mL	0.1030 mL	0.2061 mL	1.0305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc