8-Azido-ATP

Name: 8-Azido-ATP
Brand: TargetMol
SKU: T40616
Rating: 4.5 (1 reviews)

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Catalog No. T40616Cas No. 53696-59-6

Alias 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine 5'-triphosphate

8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase activity.

8-Azido-ATP

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Catalog No. T40616Alias 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine 5'-triphosphateCas No. 53696-59-6

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Product Introduction

Bioactivity

Description	8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase activity.
In vitro	8-Azido-ATP (azido-ATP) serves as an effective tool in identifying viral RNA polymerase by inhibiting transcriptional activity in rotavirus particles upon UV exposure. This compound reduces viral transcription in a dose-dependent fashion. Additionally, 8-Azido-ATP exhibits a reduced potency in blocking Kir6.2ΔC26 currents compared to ATP, with a half-maximal inhibition (Ki) observed at 2.8 ± 0.4 mM for 8-azido-ATP versus 172 ± 7 mM for ATP, indicating a lower efficacy. The Hill coefficients for 8-azido-ATP and ATP are 0.9 ± 0.2 and 1.3 ± 0.1, respectively, suggesting differences in binding affinity.
Synonyms	8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine 5'-triphosphate

Chemical Properties

Molecular Weight	548.19
Formula	C₁₀H₁₅N₈O₁₃P₃
Cas No.	53696-59-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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