Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase activity.
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Description | 8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase activity. |
In vitro | 8-Azido-ATP (azido-ATP) serves as an effective tool in identifying viral RNA polymerase by inhibiting transcriptional activity in rotavirus particles upon UV exposure. This compound reduces viral transcription in a dose-dependent fashion. Additionally, 8-Azido-ATP exhibits a reduced potency in blocking Kir6.2ΔC26 currents compared to ATP, with a half-maximal inhibition (Ki) observed at 2.8 ± 0.4 mM for 8-azido-ATP versus 172 ± 7 mM for ATP, indicating a lower efficacy. The Hill coefficients for 8-azido-ATP and ATP are 0.9 ± 0.2 and 1.3 ± 0.1, respectively, suggesting differences in binding affinity. |
Synonyms | 8-Azidoadenosine 5'-triphosphate, 8-N3-ATP, 8-Azido-ATP |
Molecular Weight | 548.194 |
Formula | C10H15N8O13P3 |
CAS No. | 53696-59-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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8-Azido-ATP 53696-59-6 8-Azidoadenosine 5'-triphosphate 8 Azido ATP 8-N3-ATP 8AzidoATP inhibitor inhibit