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Anti-Phospho-NBN (S343) Antibody (5K712)

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Catalog No. TMAC-03245

Anti-Phospho-NBN (S343) Antibody (5K712) is a Rabbit antibody targeting Phospho-NBN (S343). Anti-Phospho-NBN (S343) Antibody (5K712) can be used in WB,ICC/IF,IHC,IP.

Anti-Phospho-NBN (S343) Antibody (5K712)

Anti-Phospho-NBN (S343) Antibody (5K712)

😃Good
Catalog No. TMAC-03245
Anti-Phospho-NBN (S343) Antibody (5K712) is a Rabbit antibody targeting Phospho-NBN (S343). Anti-Phospho-NBN (S343) Antibody (5K712) can be used in WB,ICC/IF,IHC,IP.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-NBN (S343) Antibody (5K712) is a Rabbit antibody targeting Phospho-NBN (S343). Anti-Phospho-NBN (S343) Antibody (5K712) can be used in WB,ICC/IF,IHC,IP.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundNijmegen breakage syndrome (NBS) is characterized by extreme radiation sensitivity, chromosomal instability and cancer. These phenotypes are similar to those of ataxia telangiectasia mutated (ATM) disease, where there is a deficiency in a protein kinase that is activated by DNA damage, indicating that the NBS1 (Nibrin) and ATM proteins may participate in common pathways. Nibrin is specifically phosphorylated in response to gamma-radiation, ultraviolet light and exposure to hydroxyurea. The phosphorylation of Nibrin requires catalytically active ATM. ATM physically interacts with and phosphorylates Nibrin on Serine 343 both in vitro and in vivo. Serine 343 is phosphorylated in vitro by ATM and the modification of this residue in vivo is essential for the cellular response to DNA damage. This response includes S-phase checkpoint activation, formation of the NBS1/Mrel1/Rad50 nuclear foci and rescue of hypersensitivity to ionizing radiation.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human p95/NBS1 around the phosphorylation site of Ser343
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 95 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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