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Anti-Phospho-NBN (S343) Antibody (5K712)
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Catalog No. TMAC-03245
Anti-Phospho-NBN (S343) Antibody (5K712) is a Rabbit antibody targeting Phospho-NBN (S343). Anti-Phospho-NBN (S343) Antibody (5K712) can be used in WB,ICC/IF,IHC,IP.
Anti-Phospho-NBN (S343) Antibody (5K712)
Anti-Phospho-NBN (S343) Antibody (5K712)
😃Good
Catalog No. TMAC-03245
Anti-Phospho-NBN (S343) Antibody (5K712) is a Rabbit antibody targeting Phospho-NBN (S343). Anti-Phospho-NBN (S343) Antibody (5K712) can be used in WB,ICC/IF,IHC,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-Phospho-NBN (S343) Antibody (5K712) is a Rabbit antibody targeting Phospho-NBN (S343). Anti-Phospho-NBN (S343) Antibody (5K712) can be used in WB,ICC/IF,IHC,IP. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Nijmegen breakage syndrome (NBS) is characterized by extreme radiation sensitivity, chromosomal instability and cancer. These phenotypes are similar to those of ataxia telangiectasia mutated (ATM) disease, where there is a deficiency in a protein kinase that is activated by DNA damage, indicating that the NBS1 (Nibrin) and ATM proteins may participate in common pathways. Nibrin is specifically phosphorylated in response to gamma-radiation, ultraviolet light and exposure to hydroxyurea. The phosphorylation of Nibrin requires catalytically active ATM. ATM physically interacts with and phosphorylates Nibrin on Serine 343 both in vitro and in vivo. Serine 343 is phosphorylated in vitro by ATM and the modification of this residue in vivo is essential for the cellular response to DNA damage. This response includes S-phase checkpoint activation, formation of the NBS1/Mrel1/Rad50 nuclear foci and rescue of hypersensitivity to ionizing radiation. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human p95/NBS1 around the phosphorylation site of Ser343 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 95 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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