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Ethynylcytidine

Name: Ethynylcytidine
Brand: TargetMol
SKU: TQ0006
Price: 441 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0006Cas No. 180300-43-0

Alias TAS-106, ECyD, 3'-C-Ethynylcytidine

Ethynylcytidine is a nucleoside antimetabolite.

Ethynylcytidine

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Catalog No. TQ0006Alias TAS-106, ECyD, 3'-C-EthynylcytidineCas No. 180300-43-0

Ethynylcytidine is a nucleoside antimetabolite.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$117	-	In Stock
10 mg	$198	-	In Stock
25 mg	$441	-	In Stock
50 mg	Inquiry	-	In Stock
1 mL x 10 mM (in DMSO)	$128	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Ethynylcytidine is a nucleoside antimetabolite.
In vitro	The cytotoxicity of Ethynylcytidine tends to become stronger as the exposure time becomes longer. The IC50 values of Ethynylcytidine in the five human tumors with 4, 24 and 72 h exposure range from 0.114 to 1.032 μM, 0.015 to 0.067 μM, and 0.008 to 0.058 μM, respectively. The differences in IC50 values between the 24 and 72 h exposure times are not large, and Ethynylcytidine appears to show sufficiently potent cytotoxicity at the 24 h exposure time in all 5 human tumors.
In vivo	In both OCUM-2MD3 and LX-1 xenograft models, Ethynylcytidine exhibits significant tumor regression and potent antitumor efficacy, achieving a tumor growth inhibition (IR) rate of around 90% or higher by day 15 at minimally toxic doses across all three dosing schedules. A weekly administration of Ethynylcytidine at 6 mg/kg results in a substantial reduction in LX-1 tumor size, with an IR of 98%. Conversely, administering Ethynylcytidine three or five times weekly yields a strong antitumor response with an IR of approximately 85%, while a once-weekly treatment results in an IR of less than 60%, indicating comparatively weaker antitumor activity.
Synonyms	TAS-106, ECyD, 3'-C-Ethynylcytidine

Chemical Properties

Molecular Weight	267.24
Formula	C₁₁H₁₃N₃O₅
Cas No.	180300-43-0
Smiles	Nc1ccn([C@@H]2O[C@H](CO)[C@](O)(C#C)[C@H]2O)c(=O)n1
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (898.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (12.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7420 mL	18.7098 mL	37.4195 mL	187.0977 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL	37.4195 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL	18.7098 mL
20 mM	0.1871 mL	0.9355 mL	1.8710 mL	9.3549 mL
50 mM	0.0748 mL	0.3742 mL	0.7484 mL	3.7420 mL
100 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8710 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc