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AF-399/42018025
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Catalog No. T68984Cas No. 618865-88-6
AF-399/42018025 is a small-molecule antagonist of CC chemokine receptor 4 (CCR4) utilized as a research tool to investigate CCR4-mediated immune cell trafficking, inflammatory signaling, and chemokine-driven disease mechanisms, supporting studies in immunology, oncology, and inflammatory disorder models.
AF-399/42018025
😃Good
Purity: 99.96%
Catalog No. T68984Cas No. 618865-88-6
AF-399/42018025 is a small-molecule antagonist of CC chemokine receptor 4 (CCR4) utilized as a research tool to investigate CCR4-mediated immune cell trafficking, inflammatory signaling, and chemokine-driven disease mechanisms, supporting studies in immunology, oncology, and inflammatory disorder models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
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Product Introduction
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Storage & Solubility Information
| Description | AF-399/42018025 is a small-molecule antagonist of CC chemokine receptor 4 (CCR4) utilized as a research tool to investigate CCR4-mediated immune cell trafficking, inflammatory signaling, and chemokine-driven disease mechanisms, supporting studies in immunology, oncology, and inflammatory disorder models. |
| Targets&IC50 | CCR5:2 µM |
| In vitro | Method: Transgenic and wild-type mice expressing tumor-associated self antigens were immunized with vaccines combined with a small-molecule CCR4 antagonist, and CD8⁺ T-cell responses and tumor growth were evaluated in prophylactic and therapeutic models. Result: The CCR4 antagonist combined with vaccination induced effector CD8⁺ T cells against self antigens and partially inhibited tumor growth, outperforming cyclophosphamide in eliciting anti-self CD8⁺ T-cell responses[1]. |
| Molecular Weight | 566.07 |
| Formula | C26H16ClN3O4S3 |
| Cas No. | 618865-88-6 |
| Smiles | O=C(C=1OC=2C=CC=CC2C1)C3=C(O)C(=O)N(C4=NN=C(S4)SCC5=CC=C(Cl)C=C5)C3C=6SC=CC6 |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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