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LDL-IN-3

Name: LDL-IN-3
Brand: TargetMol
SKU: T10063
Price: 388 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10063 Copy Product Info

Purity: 99.75%

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LDL-IN-3 belongs to synthetic compounds and is an antioxidant and anti-atherosclerotic agent with good cell permeability and cardiovascular protective properties. This compound is used for the treatment of atherosclerosis-related diseases, effectively inhibiting oxidative stress and lipid deposition, and reducing arterial plaque formation.

Cas No. 180908-67-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$388	In Stock	In Stock
5 mg	$774	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,550	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,810	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$894	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.75%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LDL-IN-3 belongs to synthetic compounds and is an antioxidant and anti-atherosclerotic agent with good cell permeability and cardiovascular protective properties. This compound is used for the treatment of atherosclerosis-related diseases, effectively inhibiting oxidative stress and lipid deposition, and reducing arterial plaque formation.
In vitro	LDL-IN-3 inhibits low-density lipoprotein lipid peroxidation and can be used in anti-atherosclerotic studies[1].
In vivo	Methods: Female New Zealand white rabbits were fed 0.5% cholesterol/10% corn oil feed, and given 0.15% Compound I or 0.4% Compound II (dissolved in ethanol and sprayed on feed) for 70 days. Results: Compound I and II reduced total aortic lesion area by 96% and 45%, respectively, without causing elevated triglycerides. [2]

Chemical Properties

Molecular Weight	400.63
Formula	C₂₄H₃₆O₃Si
Cas No.	180908-67-2
Smiles	O(C[Si](C)(C)C1=CC=C(OC)C=C1)C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Relative Density.	1.02 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (324.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4961 mL	12.4803 mL	24.9607 mL	124.8034 mL
5 mM	0.4992 mL	2.4961 mL	4.9921 mL	24.9607 mL
10 mM	0.2496 mL	1.2480 mL	2.4961 mL	12.4803 mL
20 mM	0.1248 mL	0.6240 mL	1.2480 mL	6.2402 mL
50 mM	0.0499 mL	0.2496 mL	0.4992 mL	2.4961 mL
100 mM	0.0250 mL	0.1248 mL	0.2496 mL	1.2480 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.