Anti-MAPK14 Antibody (4C267)

Name: Anti-MAPK14 Antibody (4C267)
Brand: TargetMol
SKU: TMAY-00228
Rating: 4.5 (1 reviews)

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Anti-MAPK14 Antibody (4C267) is a Mouse antibody targeting MAPK14. Anti-MAPK14 Antibody (4C267) can be used in ELISA,ICC/IF,IHC-P,WB.

Anti-MAPK14 Antibody
(4C267)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$199	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-MAPK14 Antibody (4C267) is a Mouse antibody targeting MAPK14. Anti-MAPK14 Antibody (4C267) can be used in ELISA,ICC/IF,IHC-P,WB.
Ig Type	mouse IgG2a
Clone	4C267
Reactivity	Human
Specificity	Human p38

Application	ELISA ICC/IF IHC-P WB
Recommended Dose	WB: 1:500-1:2000; ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200; ICC-IF: 1:20-1:100
Antibody Type	Monoclonal
Host Species	Mouse
Construction	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human p38 alpha/MAPK14 (rh p38 alpha/MAPK14; NP_620581.1Met1-Ser360). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with MAPK14. The substrates of p38 alpha include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of p38 alpha in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response. In response to activation by environmental stress, pro-inflammatory cytokines, and lipopolysaccharide, MAPK14 phosphorylates some transcription factors, such as ELK1 and ATF2, and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. MAPK14 plays a critical role in the production of some cytokines, for example, IL-6. It may play a role in the stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human p38 alpha/MAPK14 Protein
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.