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Triacetin

Name: Triacetin
Brand: TargetMol
SKU: T0730
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0730Cas No. 102-76-1

Alias Glyceryl triacetate, Glycerol triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane

Triacetin (Glyceryl triacetate) is a triglyceride that is used as an antifungal agent.

Triacetin

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Purity: 98.08%

Catalog No. T0730Alias Glyceryl triacetate, Glycerol triacetate, Glycerin triacetate, 1,2,3-TriacetoxypropaneCas No. 102-76-1

Triacetin (Glyceryl triacetate) is a triglyceride that is used as an antifungal agent.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.08%

Appearance:Liquid

Color:Transparent

Resource Download

COA GC HNMR

Product Introduction

Triacetin AI Summary

Triacetin exhibits a diverse range of bioactivities with potential therapeutic applications. It is potent in modulating Lamin A splicing and selectively targets cancer cells with p53 mutations by inducing cytotoxicity. The compound acts as both an agonist and antagonist of glucocorticoid receptor signaling with varying potencies and stimulates antioxidant response element (ARE) signaling. Additionally, it displays inhibitory activity against Hepatitis C Virus (HCV) and can induce DNA re-replication in SW480 colon adenocarcinoma cells. Triacetin also antagonizes the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway and shows efficacy in blocking the entry of Ebola virus. Furthermore, Triacetin shows potent inhibition of sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells, with 98.2% and 86.74% inhibition, respectively, at a concentration of 10 μM. It has a low oil-water partition coefficient (log P of -0.36) but a slightly higher partition coefficient in ethyl ether-water (log P of 0.15), indicating a preference for the latter medium. In a DrugMatrix assay with a Daily Repeat regimen, Triacetin affects multiple parameters related to liver and kidney function, electrolyte balance, and blood cell counts, including ALT, ALB, ALP, AST, BUN, and more. Additionally, it influences red blood cells and platelet parameters significantly. Tested for antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, it showed a low level of activity with a hit score of 0.08279. Lastly, Triacetin demonstrates agonist activity at TRPA1 at a concentration of 1000 μM relative to AITC, with an activity level of 17.0%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Triacetin (Glyceryl triacetate) is a triglyceride that is used as an antifungal agent.
Synonyms	Glyceryl triacetate, Glycerol triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane

Chemical Properties

Molecular Weight	218.20
Formula	C₉H₁₄O₆
Cas No.	102-76-1
Smiles	CC(=O)OCC(COC(C)=O)OC(C)=O
Relative Density.	1.161 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (206.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (18.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5830 mL	22.9148 mL	45.8295 mL	229.1476 mL
5 mM	0.9166 mL	4.5830 mL	9.1659 mL	45.8295 mL
10 mM	0.4583 mL	2.2915 mL	4.5830 mL	22.9148 mL
20 mM	0.2291 mL	1.1457 mL	2.2915 mL	11.4574 mL
50 mM	0.0917 mL	0.4583 mL	0.9166 mL	4.5830 mL
100 mM	0.0458 mL	0.2291 mL	0.4583 mL	2.2915 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc