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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

TFMB-(R)-2-HG

🥰Excellent
Catalog No. T17065Cas No. 1445700-01-5

TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG, an oncogenic factor in acute myeloid leukemia. It impairs SCF ER-Hoxb8 cell differentiation in response to estrogen withdrawal.

TFMB-(R)-2-HG
Other Forms of TFMB-(R)-2-HG:
TFMB-(S)-2-HGT248711445703-64-9
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TFMB-(R)-2-HG

🥰Excellent
Purity: 97.15%
Catalog No. T17065Cas No. 1445700-01-5
TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG, an oncogenic factor in acute myeloid leukemia. It impairs SCF ER-Hoxb8 cell differentiation in response to estrogen withdrawal.
Pack SizePriceAvailabilityQuantity
1 mg$70In Stock
5 mg$169In Stock
10 mg$263In Stock
25 mg$476In Stock
50 mg$712In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$143In Stock
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:97.15%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG, an oncogenic factor in acute myeloid leukemia. It impairs SCF ER-Hoxb8 cell differentiation in response to estrogen withdrawal.
Chemical Properties
Molecular Weight288.22
FormulaC13H11F3O4
Cas No.1445700-01-5
SmilesFC(F)(F)c1cccc(COC(=O)[C@H]2CCC(=O)O2)c1
Relative Density.1.385 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (190.83 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.94 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4696 mL17.3479 mL34.6957 mL173.4786 mL
5 mM0.6939 mL3.4696 mL6.9391 mL34.6957 mL
10 mM0.3470 mL1.7348 mL3.4696 mL17.3479 mL
20 mM0.1735 mL0.8674 mL1.7348 mL8.6739 mL
50 mM0.0694 mL0.3470 mL0.6939 mL3.4696 mL
100 mM0.0347 mL0.1735 mL0.3470 mL1.7348 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TFMB-2-HGTFMB(R)2HGTFMB (R) 2 HGInhibitorinhibitCarcinogenic factor
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