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Tauroursodeoxycholate sodium

Name: Tauroursodeoxycholate sodium
Brand: TargetMol
SKU: T6993
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6993Cas No. 35807-85-3

Alias TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholate

Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.

Tauroursodeoxycholate sodium

🥰Excellent

Purity: 97.90%

Catalog No. T6993Alias TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholateCas No. 35807-85-3

Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.

Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$42	In Stock
100 mg	$58	In Stock
200 mg	$77	In Stock
500 mg	$119	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:97.90%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
In vivo	In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]
Cell Research	Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.
Animal Research	Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection
Synonyms	TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholate

Chemical Properties

Molecular Weight	521.69
Formula	C₂₆H₄₄NNaO₆S
Cas No.	35807-85-3
Smiles	[Na+].CC(CCC(=O)NCCS([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 10 mg/mL (19.17 mM), Sonication is recommended.

DMSO: 55 mg/mL (105.43 mM), Sonication is recommended.

H2O: 92 mg/mL (176.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9168 mL	9.5842 mL	19.1685 mL	95.8424 mL
5 mM	0.3834 mL	1.9168 mL	3.8337 mL	19.1685 mL
10 mM	0.1917 mL	0.9584 mL	1.9168 mL	9.5842 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
20 mM	0.0958 mL	0.4792 mL	0.9584 mL	4.7921 mL
50 mM	0.0383 mL	0.1917 mL	0.3834 mL	1.9168 mL
100 mM	0.0192 mL	0.0958 mL	0.1917 mL	0.9584 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc